A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamma agonists are described.
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| http://dx.doi.org/10.1016/j.bmcl.2007.01.060 | DOI Listing |
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