AI Article Synopsis
- Conditional photofragmentation is a process that uses binary systems designed with specific chemical motifs to enable targeted breakdown in response to light and external stimuli.
- The systems utilize a combination of a barbiturate recognition motif and photolabile modules like dithiane or trithiane, which only activate under the influence of a sensitizer.
- Successful fragmentation relies on a molecular recognition event that positions the sensitizer close to the photolabile module, initiating the fragmentation process.
Article Abstract
Conditional photofragmentation is achieved with binary systems incorporating the isophthaloyl bis-aminopyridine barbiturate recognition motif and dithiane- or trithiane-based photolabile modules, which cleave only in the presence of an external sensitizer. The components of the host-guest molecular recognition pair were each outfitted with either the sensitizer or the photocleavable module. In these pairs, photoinduced fragmentation is contingent on a molecular recognition event, which brings the sensitizer into the immediate proximity of the photolabile latch. [structure: see text]
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631392 | PMC |
| http://dx.doi.org/10.1021/ol0700153 | DOI Listing |
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