Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Lerodalcibep and evolocumab for the treatment of homozygous familial hypercholesterolaemia with PCSK9 inhibition (LIBerate-HoFH): a phase 3, randomised, open-label, crossover, non-inferiority trial.
Lancet Diabetes Endocrinol
January 2025
LIB Therapeutics, Cincinnati, OH, USA. Electronic address:
Background: Lerodalcibep, a small binding anti-PCSK9 protein (adnectin), showed effective LDL cholesterol reduction in heterozygous familial hypercholesterolaemia. We aimed to assess the safety and efficacy of lerodalcibep and evolocumab in a globally diverse homozygous familial hypercholesterolaemia population.
Methods: This phase 3, randomised, open-label, crossover, non-inferiority study consisted of two 24-week treatment periods separated by an 8-week washout.
From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules.
Biomolecules
January 2025
Regenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.
Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation. These biopolymers exhibit a broad molecular weight (MW) range, typically spanning from 50 to 1500 kDa. However, recent studies have expanded this range to encompass fragments as small as 1 kDa and as large as 10,000 kDa.
View Article and Find Full Text PDFWeakly Supervised Nuclei Segmentation with Point-Guided Attention and Self-Supervised Pseudo-Labeling.
Bioengineering (Basel)
January 2025
Institute of Electronic Information Engineering, Beihang University, 37 Xueyuan Road, Haidian District, Beijing 100191, China.
Due to the labor-intensive manual annotations for nuclei segmentation, point-supervised segmentation based on nuclei coordinate supervision has gained recognition in recent years. Despite great progress, two challenges hinder the performance of weakly supervised nuclei segmentation methods: (1) The stable and effective segmentation of adjacent cell nuclei remains an unresolved challenge. (2) Existing approaches rely solely on initial pseudo-labels generated from point annotations for training, and inaccurate labels may lead the model to assimilate a considerable amount of noise information, thereby diminishing performance.
View Article and Find Full Text PDFWhile telegenetic counseling has increased substantially since the start of the COVID-19 pandemic, previous studies reported concerns around building rapport, nonverbal communication, and the patient-counselor relationship. This qualitative evaluation elicited feedback from genetic counselors, referring clinicians, and patients from a single healthcare organization to understand the user-driven reasons for overall satisfaction and experience. We conducted 22 in-depth, semi-structured interviews with participants from all 3 groups between February 2022 and February 2023.
View Article and Find Full Text PDFAtmospheric pressure plasma jet for respiratory face masks decontamination and re-use: Considerations on microbiological efficacy, material impact and product lifecycle.
PLoS One
January 2025
European Commission, Joint Research Centre (JRC), Ispra, Italy.
Disposable filtering face piece respirators (FFRs) are not approved for reuse as standard of care. However, lessons learnt from the SARS-CoV-2 pandemic, FFRs decontamination and reuse may be needed as crisis capacity strategy to ensure availability in medical facilities. We studied a decontamination methodology based on atmospheric pressure plasma technology, which allows for rapid, contact-free decontamination without utilisation of harmful chemicals, and suitable to access small pores and microscopic filters openings.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!