Objective: To develop an online cell monitoring system for rapid understanding the cell's viability and functional activity, hence appropriate measures could be adopted in time.

Methods: Traditional off line technique was changed into online monitoring in this instrument for rapid detecting albumin and urea. Monocolor light source and integrated photoelectric sensor were adopted in this system.

Results: It was demonstrated in experiment that this system was designed of a novel and simple construction, which could fulfill the requirements of measuring the cell's functional activity in Bioartificial liver.

Conclusions: This design is proved feasible and reliable. It provides a novel system to monitor cell's viability and function on line quickly. Using this monitoring system, the closed-loop controlling of Bioartificial liver support system can be realized.

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http://dx.doi.org/10.1109/IEMBS.2005.1616013DOI Listing

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