Unlabelled: A novel porous polymer scaffold fabricated by salt-leaching method for tissue engineering was developed and the mechanical properties and porosity were investigated in our study. Scanning electronic microscopy (SEM) was employed to observe the morphology and structure of porous scaffolds. Cytocompatility of the porous scaffolds were evaluated, using HL-7702 cells as model, in terms of cell attachment and cell viabilities from 3 to 72 hours determined by MTT method.
Result: These scaffolds possessed a total porosity of 64.2%, compressive Young's modulus of (31.8±6.5) MPa. The particle size of porogen has little effect on the compressive properties and porosities. In addition, the morphology of pores observed by SEM showed good pore interconnectivity within the porous scaffolds. HL-7702 cell viabilities kept at high level during the whole incubation period.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/IEMBS.2005.1615567 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Double network hydrogels encapsulating genetically modified dedifferentiated chondrocytes for auricular cartilage regeneration.
J Mater Chem B
January 2025
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Microtia profoundly affects patients' appearance and psychological well-being. Tissue engineering ear cartilage scaffolds have emerged as the most promising solution for ear reconstruction. However, constructing tissue engineering ear cartilage scaffolds requires multiple passaging of chondrocytes, resulting in their dedifferentiation and loss of their special phenotypes and functions.
View Article and Find Full Text PDFTunable Bicontinuous Macroporous Cell Culture Scaffolds via Kinetically Controlled Phase Separation.
Adv Mater
January 2025
Macromolecular Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, 8092, Switzerland.
3D scaffolds enable biological investigations with a more natural cell conformation. However, the porosity of synthetic hydrogels is often limited to the nanometer scale, which confines the movement of 3D encapsulated cells and restricts dynamic cell processes. Precise control of hydrogel porosity across length scales remains a challenge and the development of porous materials that allow cell infiltration, spreading, and migration in a manner more similar to natural ECM environments is desirable.
View Article and Find Full Text PDFEvaluation of Treatment Effect and Mechanism Analysis of Ti6AL4V Porous Scaffolds Prepared by Selective Laser Melting with Different Chemical Polishing Processes.
3D Print Addit Manuf
October 2024
School of Electronics and Information Engineering, Guangdong Ocean University, Zhanjiang, China.
The large amount of unfused powder that remains on the surface of Ti6AL4V porous scaffolds prepared by selective laser melting technology is a common problem. Therefore, this article investigated the effects of three different chemical polishing processes on the surface state, pore structure, and mechanical properties of small pore size scaffold materials at different polishing times in the field of implantable medical devices. The results show that the overall treatment effect of the simple chemical polishing process is poor, the internal treatment depth of porous support is insufficient and uneven, and the overall mechanical properties of the sample with the same porosity are average.
View Article and Find Full Text PDFSelf-augmented catabolism mediated by Se/Fe co-doped bioceramics boosts ROS storm for highly efficient antitumor therapy of bone scaffolds.
Colloids Surf B Biointerfaces
December 2024
Jiangxi Province Key Laboratory of Additive Manufacturing of Implantable Medical Device, Jiangxi University of Science and Technology, Nanchang 330013, China; State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China. Electronic address:
The overexpression of glutathione (GSH) within the tumor microenvironment has long been considered as the major obstacle for reactive oxygen species (ROS)-based antitumor therapies. To address this challenge, a selenite (SeO) and ferric ion co-doped hydroxyapatite (SF-HAP) nanohybrid was synthesized, which is then introduced into poly-L-lactic acid (PLLA) to prepare porous scaffold by selective laser sintering to continuously release Fe and SeO ions. Of great significance is the released SeO catabolize GSH to generate superoxide anion (O) rather than directly eliminating GSH, thereby reversing the obstacle posed by its overexpression and achieving a "waste-to-treasure" transformation.
View Article and Find Full Text PDFZinc-doped hydroxyapatite loaded chitosan gelatin nanocomposite scaffolds as a promising platform for bone regeneration.
Biomed Mater
December 2024
Department of Paper Technology, Indian Institute of Technology Roorkee, Department of Paper Technology, IIT Roorkee, Saharanpur, 247001, INDIA.
The advancement in the arena of bone tissue engineering persuades us to develop novel nanocomposite scaffolds in order to improve antibacterial, osteogenic, and angiogenic properties that show resemblance to natural bone extracellular matrix. Here, we focused on the development of novel zinc-doped hydroxyapatite (ZnHAP) nanoparticles (1, 2 and 3 wt%; size: 50-60 nm) incorporated chitosan-gelatin nanocomposite scaffold, with an interconnected porous structure. The addition of ZnHAP nanoparticles decreases the pore size (~30 µm) of the chitosan gelatin scaffold.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!