We investigate clogging of microchannels at the single-pore level using microfluidic devices as model porous media. The process of clogging is studied at low volume fractions and high flow rates, a technologically important regime. We show that clogging is independent of particle flow rate and volume fraction, indicating that collective effects do not play an important role. Instead, the average number of particles that can pass through a pore before it clogs scales with the ratio of pore to particle size. We present a simple model that accounts for the data.
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http://dx.doi.org/10.1103/PhysRevE.74.061402 | DOI Listing |
Anal Chem
November 2024
Institute of Oncology, Cancer Hospital of Dalian University of Technology, Shenyang, Liaoning 110042, P. R. China.
The microfluidic impedance flow cytometer (m-IFC) using constricted microchannels is an appealing choice for the high-throughput measurement of single-cell mechanical properties. However, channels smaller than the cells are susceptible to irreversible blockage, extremely affecting the stability of the system and the throughput. Meanwhile, the common practice of extracting a single quantitative index, i.
View Article and Find Full Text PDFRSC Adv
October 2024
The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev Beer-Sheva 84105 Israel
Droplet-based microfluidic systems have received much attention as promising tools for fabricating monodisperse microspheres of alginate solutions with high accuracy and reproducibility. The immediate and simple ionotropic gelation of alginate, its biocompatibility, and its tunability of mechanical properties make it a favorable hydrogel in the biomedical and tissue engineering fields. In these fields, micron-sized alginate hydrogel spheres have shown high potential as cell vehicles and drug delivery systems.
View Article and Find Full Text PDFLangmuir
September 2024
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Multiple emulsions are used as templates for producing functional microcapsules due to their unique core-shell geometry. Employing glass capillary devices with coaxial channels has proven effective in creating uniform multiple-emulsion droplets. However, the use of partially miscible fluids, crucial for microcapsule production, often results in clogging and disrupts the stability of these devices.
View Article and Find Full Text PDFSci Rep
July 2024
Code 6354, Materials Science and Technology Division, Naval Research Laboratory, Washington, DC, 20375, USA.
Metallic microfluidic devices made from powder-bed additive manufacturing systems have received increasing attention, but their feasible channel geometry and complexity are often limited by lack of an effective approach to removing trapped powder particles within the channels or conduits of the sintered parts. Here, we present an innovative approach to fabricating long serpentine, high-aspect-ratio submillimeter channels made of stainless steel 316L (SS) by binder jet printing (BJP) and liquid-phase sintering. We leverage the unique nature of the BJP process, that is printing and consolidation steps are decoupled, enabling us to join two or more parts during the sintering step.
View Article and Find Full Text PDFBiomicrofluidics
July 2024
Institute for Fluid Mechanics and Aerodynamics, Bundeswehr University Munich, Werner-Heisenberg-Weg 39, 85579 Neubiberg, Germany.
This paper presents an innovative strategy to address the issues of clogging and cluster-related challenges in microchannels within microfluidic devices. Leveraging three-dimensional (3D) microbubble streaming as a dynamic solution, our approach involves the controlled activation of microbubbles near channel constrictions, inducing microstreaming with distinctive features. This microstreaming, characterized by a high non-uniform 3D gradient and significant shear stress, effectively inhibits arch formation at constrictions and disintegrates particle clusters, demonstrating real-time prevention of clogging incidents and blockages.
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