Dihydroxylation of 2-vinylaziridine: efficient synthesis of D-ribo-phytosphingosine.

Chem Commun (Camb)

Department of Chemistry and Program of Integrated Biotechnology, Sogang University, Seoul, 121-742, Korea.

Published: January 2007

An efficient and highly stereoselective synthesis of D-ribo-(2S,3S,4R)-phytosphingosine was accomplished in 62% overall yield starting from commercially available (2S)-hydroxymethylaziridine via osmium-catalyzed asymmetric dihydroxylation as a key step.

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Source
http://dx.doi.org/10.1039/b612740aDOI Listing

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