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Standardization of CD30 immunohistochemistry staining among three automated immunostaining platforms.
Pathol Int
September 2024
Department of Pathology and Laboratory Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Article Synopsis
- Identifying CD30 expression through immunohistochemistry is crucial for treating lymphomas with CD30-targeting antibody-drug conjugates, but no standardized staining protocol existed prior to this study.
- The research compared three automated immunostaining platforms (Bond III, Dako Omnis, Ventana BenchMark ULTRA) using varying dilutions of a primary antibody to determine effective staining conditions.
- The study found that adjusting antibody dilutions and cutoff values can achieve consistent CD30 staining across different platforms, with high concordance rates for diagnosing peripheral T-cell lymphomas.
Brentuximab vedotin plus cyclophosphamide, doxorubicin, etoposide, and prednisone followed by brentuximab vedotin consolidation in CD30-positive peripheral T-cell lymphomas: a multicentre, single-arm, phase 2 study.
Lancet Haematol
September 2024
Department of Lymphoma and Myeloma, UT MD Anderson Cancer Center, Houston, TX, USA.
Background: CD30 expression is universal in anaplastic large-cell lymphoma and is expressed in some other peripheral T-cell lymphoma subtypes. Incorporation of brentuximab vedotin into initial therapy for people with CD30-positive peripheral T-cell lymphomas prolonged progression-free survival, but there is room for improvement, especially for people with non-anaplastic large-cell lymphoma subtypes.
Methods: We conducted a multicentre, international, single-arm, phase 2 trial to evaluate the safety and activity of CHEP-BV (cyclophosphamide, doxorubicin, prednisone, brentuximab vedotin, and etoposide) followed by brentuximab vedotin consolidation in patients with CD30-expressing peripheral T-cell lymphomas across five academic centres in the USA and Canada.
DUSP22-rearranged primary cutaneous CD30-positive T-cell lymphoproliferative disorders and adult T-cell leukemia/lymphoma frequently share the LEF1+/TIA1- immunophenotype.
Hum Pathol
August 2024
Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan; Department of Pathology, Taipei Medical University Hospital, Taipei, 110, Taiwan; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan. Electronic address:
Article Synopsis
- DUSP22 rearrangements are genetic changes found in certain types of lymphomas, particularly in systemic and primary cutaneous anaplastic large cell lymphoma, as well as lymphomatoid papulosis, with previous studies mainly highlighting S-ALCL.
- This study examined LEF1/TIA1 expression and MSC mutations in 23 cases of C-ALCL and LyP, finding DUSP22 rearrangements in eight cases and LEF1 expression present in 63% of those cases, while TIA1 was negative across the board.
- The research indicated that the rate of LEF1 expression in DUSP22-rearranged C-ALCL/LyP is lower than that in S-ALCL
[Clinicopathological features of primary mucosal CD30-positive T-cell lymphoproliferative disorders].
Zhonghua Bing Li Xue Za Zhi
July 2024
Department of Pathology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China.
Article Synopsis
- The study focused on the clinicopathological features and differential diagnosis of primary mucosal CD30-positive T-cell lymphoproliferative disorders (pmCD30TLPD) by reviewing cases diagnosed between 2013 and 2023.
- Eight cases were analyzed, revealing that most patients were middle-aged, with lesions primarily in the oral and anal mucosa, showing various morphological characteristics and immunophenotypes.
- Despite the potential for misdiagnosis with other lymphoproliferative disorders, most patients had favorable outcomes, with only one succumbing to complications, emphasizing the importance of careful diagnosis and monitoring.
Intraoral CD30+ T-Cell Lymphoproliferative Disorder with Lymphomatoid Papulosis Type C Features Mimics Lymphoma Histopathologically and Immunohistochemically.
Head Neck Pathol
June 2024
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School, University of São Paulo (FORP/USP), Ribeirão Preto, SP, 14040-904, Brazil.
Article Synopsis
- * Histopathology revealed atypical lymphoid cells showing specific markers, raising concerns for anaplastic large cell lymphoma (ALCL), though the ulcer healed completely within three weeks.
- * The authors conclude that this case represents a rare type of intraoral CD30+ T-cell LPD, which they believe corresponds to cutaneous LyP type C, highlighting its diagnostic challenges.
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