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Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.
Front Endocrinol (Lausanne)
December 2024
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Background: Evidence indicates a negative link between glucosamine and age-related cognitive decline and sarcopenia. However, the causal relationship remains uncertain. This study aims to verify whether glucosamine is causally associated with cognitive function and sarcopenia.
View Article and Find Full Text PDFThe association between the healthy lifestyle index and MRI-derived body composition measurements in the UK Biobank study.
Sci Rep
January 2025
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue Belfer, Rm1301, Bronx, NY, 10461, USA.
A high healthy lifestyle index (HLI) score, which reflects an adequate amount of sleep, no alcohol consumption, no smoking, a moderate to high physical activity level, a high quality diet, and a normal body mass index (BMI), has been associated with reduced risk of morbidity and mortality. We examined the relationship between the HLI and measurements of adipose and lean tissue volumes measured using magnetic resonance imaging (MRI). We studied 33,002 participants in the UK Biobank study, aged 40-69 years at enrolment.
View Article and Find Full Text PDFEffectiveness of Low Doses of Semaglutide on Weight Loss and Body Composition Among Women in Their Menopause.
Metab Syndr Relat Disord
January 2025
Clínica Rotger (Grupo Quirón), Vía Roma, Baleares, Spain.
Menopause is a complex period in women's life, when weight gain and predisposition to obesity are frequent. Moreover, even during menopause transition, women begin to lose lean mass up to 0.5% and, therefore, an increase in the percentage of fat mass with central distribution and an increased risk of metabolic syndrome.
View Article and Find Full Text PDFUncontrolled asthma is Associated with Increased Visceral Adipose Tissue, Decreased Bone Mineral Content, and Reduced Exercise Capacity.
J Asthma Allergy
December 2024
Respiratory Medicine, University Hospital of Liège, Liège, Belgium.
Introduction: Physical inactivity due to shortness of breath is common among patients with uncontrolled asthma. We evaluated the body mass composition and exercise capacity of patients with poorly controlled asthma, despite maximal inhalation therapy.
Methods: We recruited 56 patients from the Asthma Clinic of the University Hospital of Liège between September 2020 and December 2023, and 14 healthy subjects.
Ghrelin: An Emerging Therapy for Heart Failure.
Clin Endocrinol (Oxf)
January 2025
Department of Cardiology & 65+ Clinic, Sismanogleio-Amalia Fleming General Hospital, Melissia, Greece.
Objective: Ghrelin is emerging as a promising therapeutic option for heart failure (HF) due to its potent inotropic, anabolic, and cardioprotective properties. This review aims to critically examine the available clinical evidence on ghrelin therapy in HF, while also incorporating key findings from preclinical studies that support its therapeutic potential.
Methods: A comprehensive search was conducted in PubMed and the Cochrane Library up to September 15, 2024, using the keywords "heart failure" and "ghrelin.
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