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[Chronic epidural spinal cord stimulation for gait impairments in Parkinson's disease and atypical parkinsonism].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Burnasian State Research Medical Center, Moscow, Russia.
Article Synopsis
- Spinal cord stimulation is a minimally invasive surgery used to treat chronic pain, and has recently gained attention for helping patients with advanced Parkinson's disease and atypical parkinsonism.
- Recent studies show it can improve gait issues, particularly the freezing of gait, which is a common and debilitating symptom in these conditions.
- This review highlights the effectiveness of chronic epidural spinal cord stimulation in reducing locomotor problems, especially in patients who don’t respond well to traditional therapies.
A systematic review of stepped wedge cluster randomized trials in high impact journals: assessing the design, rationale, and analysis.
J Clin Epidemiol
December 2024
Edinburgh Clinical Trials Unit, Usher Institute, The University of Edinburgh, Usher Building, 5-7 Little France Road, Edinburgh BioQuarter - Gate 3, Edinburgh EH16 4UX, UK. Electronic address:
Objectives: Stepped wedge cluster randomized trials (SW-CRTs) are an appealing study design because they enable sequential roll out of an intervention across clusters, bringing logistical advantages. This review aimed to evaluate the design rationale, design features, stepped wedge diagram, and analytical approaches of SW-CRTs published in high-impact medical journals from 2020 to 2023, focusing particularly on adherence to key guidelines from the Consolidated Standards of Reporting Trials extension to SW-CRTs.
Study Design And Setting: We conducted searches across PubMed and Cochrane Central Registry of Controlled Trials databases for SW-CRTs published between January 2020 and December 2023 in eight high-impact journals.
System-level Variability in Trauma Center Utilization for Seriously Injured Older Adults.
J Surg Res
November 2024
Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts; The Gillian Reny Stepping Strong Center for Trauma Innovation, Boston, Massachusetts. Electronic address:
Introduction: Many seriously injured older adults are not transported to trauma centers (TCs), a phenomenon known as undertriage. System-level factors that contribute to undertriage are poorly understood. One important system-level factor is the regional supply of TCs.
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