Bezoar-related pancreatitis in enterically drained pancreas transplant.

Transplant Proc

Lillian Jean Kaplan Renal Transplant Center of the Division of Transplantation of the Department of Surgery, at the University of Miami, Leonard M Miller School of Medicine, Miami, FL 33136, USA.

Published: April 2007

Simultaneous kidney and pancreas transplantation is currently the treatment of choice for type 1 diabetes mellitus with end-stage renal disease. As a result of improvements in surgical techniques and the efficacy of immunosuppression, patient and graft survival rates have improved dramatically over the last two decades. Despite this, it remains a challenging surgical procedure with many potential complications and occasional controversies. Causes of pancreatitis after pancreas transplantation with enteric drainage are not well documented in the literature. We report a case of allograft pancreatitis from pancreatic duct outflow obstruction due to formation of a bezoar in a diverticulized transplant duodeno-jejunal anastomosis. To the best of our knowledge, this is the first case of allograft pancreatitis reported in the literature occurring from bezoar formation.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2006.10.024DOI Listing

Publication Analysis

Top Keywords

pancreas transplantation
8
case allograft
8
allograft pancreatitis
8
bezoar-related pancreatitis
4
pancreatitis enterically
4
enterically drained
4
drained pancreas
4
pancreas transplant
4
transplant simultaneous
4
simultaneous kidney
4

Similar Publications

Simultaneous pancreas-kidney (SPK) transplantation is a recognized treatment for patients with insulin-dependent diabetes and advanced chronic kidney disease or end-stage renal disease (ESRD), offering significant survival benefits. However, it is associated with a higher risk of venous thrombosis, which can jeopardize the survival of the pancreaticoduodenal graft. This case report describes a patient with type 2 diabetes, hypertension, and ESRD who developed acute, occlusive deep vein thrombosis (DVT) involving the right common femoral, profunda femoral, and greater saphenous veins on postoperative day 1 (POD1) following a deceased donor SPK transplant, despite systemic prophylactic anticoagulation.

View Article and Find Full Text PDF

Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon-γ-mediated pathway.

Am J Transplant

December 2024

The Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095; Department of Surgery, Medical University of South Carolina, Charleston, SC 29425. Electronic address:

As important immune regulatory cells, whether innate lymphoid cells (ILCs) are involved in liver transplantation (LT) remains unclear. In a murine orthotopic LT model, we dissected roles of ILCs in liver ischemia-reperfusion injury (IRI). Wild type (WT) grafts suffered significantly higher IRI in Rag2-γc double knockout (DKO) than Rag2 KO recipients, in association with downregulation of group 1 ILCs genes, including IFN-γ.

View Article and Find Full Text PDF

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal and common form of pancreatic cancer, it has no specific symptoms, and most of the patients are diagnosed when the disease is already at an advanced stage. Chemotherapy typically has only a modest effect, making surgery the most effective treatment option. However, only a small percentage of patients are amenable to surgery.

View Article and Find Full Text PDF

Pancreatic ductal adenocarcinoma (PDAC) is characterized by its poor prognosis. Traditional Japanese herbal medicine (Kampo), such as Juzentaihoto (a standardized combination of 10 herbal extracts), has shown immune modulatory effects, modulation of microcirculation, and amelioration of fatigue. It is administered to patients to prevent deterioration of cachexia and counteract side effects of chemotherapy.

View Article and Find Full Text PDF

Background: The clinical impact of bariatric surgery (BS) prior to pancreas transplantation (PTx) is unclear.

Setting: University of Minnesota Hospital, Minneapolis, MN.

Methods: This was a single center retrospective case-controlled study of all patients January 1, 1998 and May 1, 2024 with a history of BS prior to PTx.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!