This study deals with cytotoxicity assays performed on an array of commercially manufactured inorganic nanoparticulate materials, including Ag, TiO(2), Fe(2)O(3), Al(2)O(3), ZrO(2), Si(3)N(4), naturally occurring mineral chrysotile asbestos and carbonaceous nanoparticulate materials such as multiwall carbon nanotube aggregates and black carbon aggregates. The nanomaterials were characterized by TEM, as the primary particles, aggregates or long fiber dimensions ranged from 2nm to 20microm. Cytotoxicological assays of these nanomaterials were performed utilizing a murine alveolar macrophage cell line and human macrophage and epithelial lung cell lines as comparators. The nanoparticulate materials exhibited varying degrees of cytoxicity for all cell lines and the general trends were similar for both the murine and human macrophage cell lines. These findings suggest that representative cytotoxic responses for humans might be obtained by nanoparticulate exposures to simple murine macrophage cell line assays. Moreover, these results illustrate the utility in performing rapid in vitro assays for cytotoxicity assessments of nanoparticulate materials as a general inquiry of potential respiratory health risks in humans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.actbio.2006.11.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Magnetite Nanoparticles Encapsulated with PBS-PEG for AMF Hyperthermia.
Materials (Basel)
January 2025
University Centre for Research and Development (UCRD), Department of Physics, Chandigarh University, Mohali 140413, Punjab, India.
Novel studies on typical synthesized magnetite nanoparticles were encapsulated into a poly (butylene succinate)/poly (ethylene glycol) copolymer (PBS-PEG). PBS was chosen because of its biocompatibility characteristics necessary for biomedical applications. PEG, as part of the macromolecular structure, increases the hybrid system's solubility in an aqueous environment, increasing the circulation time of the material in the bloodstream.
View Article and Find Full Text PDFEffect of In Situ Acid Erosion on Structural and Optical Properties of Nanoparticulated Bisacrylic Resin With Different Surface Treatments.
J Esthet Restor Dent
January 2025
Department of Dental Materials and Prosthodontics, Sao Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil.
Objective: To evaluate the influence of in situ acid erosion on the structural and optical properties of nanoparticulate bisacrylic resin with different surface treatments, evaluating surface roughness (Ra), knoop microhardness (KHN), color change (ΔE, ΔL, ΔC, ΔH), contrast (CR) and translucency (TP).
Methods: Eighty specimens were made (n = 10 per group) and the following surface treatments were applied: U-unpolished; A-polishing with Astropol rubber tips (Ivoclar); S-Biscover LV surface sealant (Bisco) and S-Palaseal surface sealant (kulzer). For the in situ experiment, 10 volunteers wore an intraoral appliance containing eight specimens (two specimens per experimental group), with only one specimen from each experimental group being subjected to the acid process.
Defect-Mediated Crystallization of the Particulate TiO Photocatalyst Grown by Atomic Layer Deposition.
J Phys Chem C Nanomater Interfaces
January 2025
Surface Science Laboratory, Faculty of Engineering and Natural Sciences, Tampere University, P.O. Box 692, FI-33014 Tampere, Finland.
Nanopowders or films of pure and mixed oxides in nanoparticulate form have gained specific interest due to their applicability in functionalizing high-surface-area substrates. Among various other applications, our presented work primarily focuses on the behavior of TiO as a photocatalyst deposited by atomic layer deposition (ALD) on a quartz particle. The photocatalytic activity of TiO on quartz particles grown by ALD was studied in terms of ALD growth temperature and post-treatment heating rate.
View Article and Find Full Text PDFSpatiotemporal Dynamic Immunomodulation by Infection-Mimicking Gels Enhances Broad and Durable Protective Immunity Against Heterologous Viruses.
Adv Sci (Weinh)
January 2025
SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.
Despite their safety and widespread use, conventional protein antigen-based subunit vaccines face significant challenges such as low immunogenicity, insufficient long-term immunity, poor CD8 T-cell activation, and poor adaptation to viral variants. To address these issues, an infection-mimicking gel (IM-Gel) is developed that is designed to emulate the spatiotemporal dynamics of immune stimulation in acute viral infections through in situ supramolecular self-assembly of nanoparticulate-TLR7/8a (NP-TLR7/8a) and an antigen with tannic acid (TA). Through collagen-binding properties of TA, the IM-Gel enables sustained delivery and enhanced retention of NP-TLR7/8a and protein antigen in the lymph node subcapsular sinus of mice for over 7 days, prolonging the exposure of vaccine components in both B cell and T cell zones, leading to robust humoral and cellular responses.
View Article and Find Full Text PDFSustained release of Ambrisentan solid lipid nanoparticles for the treatment of hypertension: Melt emulsification method.
Ann Pharm Fr
January 2025
SVKM's NMIMS School of Pharmacy and Technology Management Shirpur, Dhule 425405, India; Department of Pharmaceutical Quality Assurance, SVKM Institute of Pharmacy, Dhule 424001, Maharashtra, India. Electronic address:
Objective: The beneficial usefulness is limited because of its deprived solubility and bioavailability. The recent work deals with the advancement of solid lipid nanoparticles of Ambrisentan for the effective therapy of pulmonary hypertension intended for oral delivery.
Material And Methods: The solid lipid nanoparticles of Ambrisentan were developed using the melt emulsification method.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!