Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems.
Biofactors
December 2024
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Thiamine (vitamin B1), under the proper conditions, is able to reversibly open the thiazole ring, forming a thiol-bearing molecule that can be further oxidized to the corresponding disulfide. To improve the bioavailability of the vitamin, several derivatives of thiamine in the thioester or disulfide form were developed and extensively studied over time, as apparent from the literature. We have examined three thiamine-derived disulfides: thiamine disulfide, sulbutiamine, and fursultiamine with reference to their intervention in modulating the thiol redox state.
View Article and Find Full Text PDFPharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes.
Biochemistry (Mosc)
July 2024
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Article Synopsis
- - Charcot-Marie-Tooth (CMT) neuropathy is a genetic disorder affecting peripheral nerves, with thiamine (vitamin B1) potentially improving symptoms; this study explores thiamine’s effects when taken daily.
- - Patients showed improved hand grip strength with thiamine and its derivatives (sulbutiamine and benfotiamine), but no significant differences in thiamine-related blood levels were found compared to healthy controls.
- - Interestingly, while thiamine raised grip strength, it also reduced certain enzyme levels (holo-transketolase) in CMT patients, and the way transketolase was activated by thiamine differed between the CMT group and controls, highlighting complex
Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine.
Biofactors
August 2024
Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
The prevalence of testicular dysfunction is increasing as it is a common diabetes mellites (DM) complication. The objective of this study is to explore the potential protective effect of sulbutiamine against testicular hypofunction associated with streptozotocin (STZ)-induced DM in rats. Sulbutiamine was administered orally (60 mg/kg) to male Wistar rats for 8 weeks starting 72 h after a single injection of STZ (45 mg/kg, i.
View Article and Find Full Text PDFRegulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats.
Chem Biol Interact
August 2023
Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:
One of the serious complications of diabetes mellitus is diabetic nephropathy (DN) which may finally lead to renal failure. The current study aimed to explore the effect of sulbutiamine, a synthetic derivative of vitamin B1, in streptozotocin (STZ)-induced DN and related pathways. Experimental DN was successfully induced 8 weeks after a single low dose of STZ (45 mg/kg, I.
View Article and Find Full Text PDFIn this article, we try to present the available data regarding the pharmacokinetics and pharmacodynamics of sulbutiamine (Enerion), the mechanisms of its anti-asthenic action. Then we analyze and summarize the available evidence base considering the efficacy and safety of Enerion for the treatment of asthenic syndromes. Then we compare Enerion with some other drugs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!