The purpose of this paper is to present preliminary evidence that data mining and artificial intelligence systems may allow one to recognize the presence and severity of motor fluctuations in patients with Parkinson's disease (PD). We hypothesize that movement disorders in late-stage PD present with identifiable and predictable features that can be derived from accelerometer (ACC) and surface electromyographic (EMG) signals recorded during the execution of a standardized set of motor assessment tasks. Although this paper focuses on a specific clinical application requiring advanced analysis techniques, the approach can be generalized to numerous applications in which data mining and other techniques can be used to analyze large data sets derived from wearable sensors.
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http://dx.doi.org/10.1109/IEMBS.2004.1404319 | DOI Listing |
Am J Drug Alcohol Abuse
January 2025
School of Nursing and Health Sciences, Hong Kong Metropolitan University, Hong Kong, China.
Drug use among men is a significant public health concern in China, with compulsory drug treatment centers being the primary approach. Police officers in these centers play a crucial role in shaping the interactions and experiences of men who use drugs (MWUD). However, little research exists on the attitudes of police officers toward MWUD in China.
View Article and Find Full Text PDFUnlabelled: Once considered rare in eukaryotes, polycistronic mRNA expression has been identified in kinetoplastids and, more recently, green algae, red algae, and certain fungi. This study provides comprehensive evidence supporting the existence of polycistronic mRNA expression in the apicomplexan parasite . Leveraging long-read RNA-seq data from different parasite strains and using multiple long-read technologies, we demonstrate the existence of defined polycistronic transcripts containing 2-4 protein encoding genes, several validated with RT-PCR.
View Article and Find Full Text PDFNatural products have long been a rich source of diverse and clinically effective drug candidates. Non-ribosomal peptides (NRPs), polyketides (PKs), and NRP-PK hybrids are three classes of natural products that display a broad range of bioactivities, including antibiotic, antifungal, anticancer, and immunosuppressant activities. However, discovering these compounds through traditional bioactivity-guided techniques is costly and time-consuming, often resulting in the rediscovery of known molecules.
View Article and Find Full Text PDFFront Immunol
January 2025
Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, China.
Introduction: Brucellosis is a widespread zoonotic disease that poses a considerable challenge to global public health. Existing diagnostic methods for this condition, such as serological assays and bacterial culture, encounter difficulties due to their limited specificity and high operational complexity. Therefore, there is an urgent need for the development of enhanced diagnostic approaches for brucellosis.
View Article and Find Full Text PDFHealth Sci Rep
January 2025
Research Center for Environmental Determinants of Health (RCEDH), Health Institute Kermanshah University of Medical Sciences Kermanshah Iran.
Background And Aims: Infertility, as defined by the World Health Organization, is the inability to conceive after 12 months of regular, unprotected intercourse. This study aimed to identify factors influencing infertility by applying data mining techniques, specifically rule-mining methods, to analyze diverse patient data and uncover relevant insights. This approach involves a thorough analysis of patients' clinical characteristics, dietary habits, and overall conditions to identify complex patterns and relationships that may contribute to infertility.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!