AI Article Synopsis
- The text discusses the structure-activity relationship (SAR) development of N-acyl pyrrolidine compounds that inhibit the Hepatitis C virus by targeting the NS5B enzyme.
- It highlights the progression from easily manageable Delta21 enzyme inhibitors to compounds that show antiviral activity in cell tests using an HCV replicon model.
- The work aims to contribute to the development of effective treatments for Hepatitis C by enhancing the understanding of how these inhibitors function.
Article Abstract
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon).
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| http://dx.doi.org/10.1016/j.bmcl.2007.01.034 | DOI Listing |
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