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Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes.
Cell Commun Signal
December 2024
EV group, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, and CURED, Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki, Viikinkaari 9, Helsinki, 00790, Finland.
Background: Beyond their conventional roles in hemostasis and wound healing, platelets have been shown to facilitate hematogenous metastasis by interacting with cancer cells. Depending on the activation route, platelets also generate different platelet-derived extracellular vesicles (PEVs) that may educate cancer cells in the circulation or within the tumor microenvironment. We engaged different platelet-activating receptors, including glycoprotein VI and C-type lectin-like receptor 2, to generate a spectrum of PEV types.
View Article and Find Full Text PDFIsorhynchophylline inhibits platelet activation and thrombus formation.
J Cardiovasc Pharmacol
December 2024
Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China.
Article Synopsis
- Isorhynchophylline, a Chinese herbal medicine, shows anti-inflammatory and neuroprotective effects, but its impact on platelet function was previously unknown.
- The study found that isorhynchophylline reduces platelet aggregation and activation in a dose-dependent manner and does not affect surface levels of key receptors.
- In vivo tests on mice indicated that isorhynchophylline impairs hemostatic function and thrombus formation, suggesting it might be useful for treating thrombotic and cardiovascular diseases.
Strategic enhancement of collagen detection using lanthanide-functionalized collagen targeted peptides.
Talanta
February 2025
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China. Electronic address:
Monitoring collagen denaturation is crucial for diagnosing collagen-related diseases such as tumors and fibrosis. Herein, we have developed specific probes to detect denatured collagen (d-Col) and collagen I (Col I), utilizing peptide probes with sequences (GOP) and HVWMQAP, targeting at d-Col and Col I, respectively. These peptides were conjugated with 1,10-phenanthroline-5-carboxylic Acid (Phen), forming Phen-Ahx-(GOP) and Phen-Ahx-HVWMQAP.
View Article and Find Full Text PDFFunctional characterization of a nanobody-based glycoprotein VI-specific platelet agonist.
Res Pract Thromb Haemost
October 2024
Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders. GPVI can be activated by inducing receptor clustering with suspensions of fibrillar collagen or synthetic cross-linked collagen-related peptide (CRP-XL).
View Article and Find Full Text PDFNAT10-mediated RNA ac4C acetylation contributes to the myocardial infarction-induced cardiac fibrosis.
J Cell Mol Med
November 2024
Department of Pediatric, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Cardiac fibrosis is featured cardiac fibroblast activation and extracellular matrix accumulation. Ac4C acetylation is an important epigenetic regulation of RNAs that has been recently discovered, and it is solely carried out by NAT10, the exclusive enzyme used for the modification. However, the potential regulatory mechanisms of ac4C acetylation in myocardial fibrosis following myocardial infarction remain poorly understood.
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