We describe a case of successful percutaneous closure of a moderate-sized paravalvular leak using the Amplatzer septal occluder device in a patient with excessive surgical risk. We were able to successfully close the paravalvular leak without interfering with normal prosthetic valve leaflet function. In patients with severe periprosthetic mitral regurgitation refractory to aggressive medical therapy who are not candidates for surgical intervention, use of the Amplatzer septal occluder device offers an attractive percutaneous treatment option.
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