Objective: Current practice guidelines discourage use of lithium during breast-feeding, despite limited data. This study aimed to quantify lithium exposure in nursing infants.
Method: In 10 mother-infant pairs, the authors obtained assays of lithium in maternal serum, breast milk, and infant serum and indices of infant renal and thyroid function.
Results: Maternal serum, breast milk, and infant serum daily trough concentrations of lithium averaged 0.76, 0.35, and 0.16 meq/liter, respectively, each lithium level lower than the preceding level by approximately one-half. No serious adverse events were observed, and elevations of thyroid-stimulating hormone, blood urea nitrogen, and creatinine were few, minor, and transient.
Conclusions: Serum lithium levels in nursing infants were low and well tolerated. No significant adverse clinical or behavioral effects in the infants were noted. These findings encourage reassessment of recommendations against lithium during breast-feeding and underscore the importance of close clinical monitoring of nursing infants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1176/ajp.2007.164.2.342 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human milk whey proteins: Constituents, influencing factors, detection methods, and comparative analysis with other sources.
Food Chem X
January 2025
Key Laboratory of Dairy Science, Ministry of Education, Food Science College, Northeast Agricultural University, Harbin, 150030, China.
Whey proteins, the most abundant proteins in human milk (HM), play a vital role in the growth and development of infants. This review first elaborates on the main components of HM whey proteins, including various proteins with specific functions, and details the functions of these proteins in terms of infant nutrition, immunity, as well as growth and development. Secondly, it analyzes factors that affect HM whey proteins, such as maternal differences, dietary habits, and geographical differences.
View Article and Find Full Text PDFPrevalence, spatial variation and associated factors of mixed milk feeding among mothers with infants aged 0-6 months in Ethiopia: a spatial and multilevel analysis.
BMJ Open
December 2024
Department of Reproductive Health, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Objective: This study aimed to determine the prevalence, spatial variation and associated factors of mixed milk feeding practice among mothers with infants aged 0-6 months in Ethiopia.
Study Design: A cross-sectional study design was used.
Setting: The study was conducted in Ethiopia.
Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage.
J Biol Eng
January 2025
Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, 24016, USA.
Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. However, maintaining integrity and bioactivity of EVs between Good Manufacturing Practice separation/filtration and end-user application remains a consistent bottleneck towards commercialization. Milk-derived extracellular vesicles (mEVs), separated from bovine milk, could provide a relatively low-cost, scalable platform for large-scale mEV production; however, the reliance on cold supply chain for storage remains a logistical and financial burden for biologics that are unstable at room temperature.
View Article and Find Full Text PDFInfluenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines.
NPJ Vaccines
January 2025
ISP, INRAE, Université de Tours, Nouzilly, France.
Influenza, a major "One Health" threat, has gained heightened attention following recent reports of highly pathogenic avian influenza in dairy cattle and cow-to-human transmission in the USA. This review explores general aspects of influenza A virus (IAV) biology, its interactions with mammalian hosts, and discusses the key considerations for developing vaccines to prevent or curtail IAV infection in the bovine mammary gland and its spread through milk.
View Article and Find Full Text PDFGood fat vs bad fat in Milk: A molecular level Understanding of Indian cow milk using confocal Raman microscopy.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address:
Milk, a complex fluid renowned for abundance of vitamins and immune-boosting antibodies, holds a pivotal position in human nutrition. The research delves into the fundamental constituents of milk, focusing on cis-fatty acids (cis-FA), trans-fatty acids (trans-FA), and theα-helixstructure found in proteins. These constituents are instrumental in the determination of milk quality and its nutritional value.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!