A coumarin-based europium chelate ready-to-use for analyte labeling and homogeneous time-resolved fluorescence measurements has been designed. Compound 1 displays three functional elements: an azide reactive spacer arm, a coumarin sensitizer, and a seven-coordinate europium complex. That complex can be excited at 370 nm by inexpensive UV-LEDs as a light excitation source.
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New Coumarin Dipicolinate Europium Complexes with a Rich Chemical Speciation and Tunable Luminescence.
Molecules
February 2021
Fondazione Pisana per la Scienza, Via F. Giovannini 13, 56017 San Giuliano Terme (PI), Italy.
Europium (III) luminescent chelates possess intrinsic photophysical properties that are extremely useful in a wide range of applications. The lack of examples of coumarin-based lanthanide complexes is mainly due to poor photo-sensitization attempts. However, with the appeal of using such a versatile scaffold as antenna, especially in the development of responsive molecular probes, it is worth the effort to research new structural motifs.
View Article and Find Full Text PDFA versatile long-wavelength-absorbing scaffold for Eu-based responsive probes.
Chemistry
February 2013
Department of Chemistry, BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.
Coumarin-sensitized, long-wavelength-absorbing luminescent Eu(III)-complexes have been synthesized and characterized. The lanthanide binding site consists of a cyclen-based chelating framework that is attached through a short linker to a 7-hydroxycoumarin, a 7-B(OH)(2)-coumarin, a 7-O-(4-pinacolatoboronbenzyl)-coumarin or a 7-O-(4-methoxybenzyl)-coumarin. The syntheses are straightforward, use readily available building blocks, and proceed through a small number of high-yielding steps.
View Article and Find Full Text PDFSynthesis and characterization of coumarin-based europium complexes and luminescence measurements in aqueous media.
Org Biomol Chem
December 2009
Laboratoire de Chimie Organique Appliquée, C.A.M.B., UMR 7199 CNRS-UdS, Faculté de Pharmacie, 74 route du Rhin-BP 60024, 67401, Illkirch Cedex, France.
A series of new ligands suitable for the formation of luminescent lanthanide complexes in water is described. The chelates are designed for analyte labeling and play the role of fluorescent donor in homogeneous time-resolved fluorescence assays using LEDs as a light source for excitation at 370 nm. Ligands are constructed from a coumarin nucleus, for lanthanide sensitization, and different aminomethylenecarboxy moieties are introduced in positions 7 and 5, 6, or 8 of the sensitizer.
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Bioorg Med Chem Lett
March 2007
Institut Gilbert-Laustriat, CNRS-Université Louis Pasteur, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch Cedex, France.
A coumarin-based europium chelate ready-to-use for analyte labeling and homogeneous time-resolved fluorescence measurements has been designed. Compound 1 displays three functional elements: an azide reactive spacer arm, a coumarin sensitizer, and a seven-coordinate europium complex. That complex can be excited at 370 nm by inexpensive UV-LEDs as a light excitation source.
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