AI Article Synopsis
- Alpha-GalCer is a powerful antigen that activates natural killer T cells, and researchers have created modified versions called triazole analogues with varying lipid chain lengths.
- These triazole analogues replace a part of the alpha-GalCer structure and lead to a greater production of IL-4 compared to IFN-gamma, indicating a shift towards a Th2 immune response.
- Notably, the longer lipid chains on the triazole analogues result in a stimulatory effect on cytokine production that is similar to alpha-GalCer and enhances Th2 responses even more.
Article Abstract
alpha-GalCer is the first defined and most potent agonistic antigen of the T cell receptor of natural killer T cells. We have prepared a series of 1,2,3-triazole-containing alpha-GalCer analogues in which the lipid chain lengths have been incrementally varied. We found that this isosteric replacement of alpha-GalCer's amide moiety with triazole increases the IL-4 versus IFN-gamma bias of released cytokines. The stimulatory effect was influenced by the length of the attached chain. In particular, the long-chained triazole analogues have a comparable stimulatory effect on cytokine production as alpha-GalCer and exhibit a stronger Th2 cytokine response.
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| http://dx.doi.org/10.1021/jm061243q | DOI Listing |
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