The immune-privileged status of the anterior chamber of the eye is altered in experimentally induced intraocular inflammation and in the pigment dispersion syndrome of DBA/2J mice. However, the eye has developed multiple mechanisms to maintain ocular immune privilege even in the presence of intraocular inflammation.
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Nat Commun
March 2025
Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education); Key Laboratory of Immune Microenvironment and Disease (Ministry of Education); The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, Tianjin Medical University; Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
As a crucial element of proteolysis targeting chimeras (PROTACs), the choice of E3 ubiquitin ligase significantly influences degradation efficacy and selectivity. However, the available arsenal of E3 ligases for PROTAC development remains underexplored, severely limiting the scope of targeted protein degradation. In this study, we identify a non-inhibitory aptamer targeting ZYG11B, a substrate receptor of the Cullin 2-RING ligase complex, as an E3 warhead for targeted protein degradation.
View Article and Find Full Text PDFBiochem Pharmacol
March 2025
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. Electronic address:
Autoimmune toxicity affects up to 60 % of patients receiving immune checkpoint inhibitor (ICI) therapy for cancer, presenting a notable clinical obstacle that constrains its wider application. Hence, there is an imperative demand to develop novel strategies to manage immune-related adverse events (irAEs). Ifosfamide (IFO) shares structural and functional resemblances with cyclophosphamide (CPA).
View Article and Find Full Text PDFPraxis (Bern 1994)
February 2025
Entzündungssprechstunde, Klinik und Poliklinik für Innere Medizin, Universitätsspital Zürich.
The VEXAS syndrome is a systemic autoinflammatory disease first described in 2020. It primarily affects older men and is caused by a somatic mutation in the UBA1 gene on the X chromosome, leading to dysfunction of the innate immune system. Symptoms include fever, weight loss, various hematological manifestations, and a broad spectrum of clinical symptoms, often including ocular manifestations.
View Article and Find Full Text PDFFront Immunol
March 2025
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Introduction: The molecular pathogenesis of ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma and IgG4-related ophthalmic disease (IgG4-ROD) remains incompletely understood. Differentiating between the two diseases is vital given that the diagnostic evaluation and treatment approaches can vary significantly; this difficulty in distinction is exacerbated by the absence of specific biomarkers. This study aimed to investigate the differences between these two diseases based on their cellular composition, transcriptional heterogeneity, and the immune microenvironment using single-cell RNA transcriptional sequencing (scRNA-seq) technology.
View Article and Find Full Text PDFJFMS Open Rep
March 2025
Department of Infectious Diseases, University of Georgia, Athens, GA, USA.
Objectives: The objective of this study was to retrospectively assess the pathogens associated with feline ocular and respiratory diseases in routine diagnostic samples submitted to Georgia Veterinary Diagnostic Laboratories. Furthermore, pathogens detected by the respiratory PCR panel in the upper vs lower respiratory tract were compared (specimen separation at pharynx).
Methods: Test records from feline ocular and respiratory PCR panels were collected from 2012 to 2022.
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