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Atypical presentations of primary lymphoproliferative processes in the central nervous system.
Radiologia (Engl Ed)
December 2024
Servicio de Radiología, Hospital Universitario Doce de Octubre, Madrid, Spain.
Central nervous system (CNS) involvement by lymphoproliferative disorders is rare and associated with a poor prognosis. CNS involvement can be exclusive, primary or appear in a secondary manner as part of a systemic process. The spectrum of involvement that we encounter is varied and neuroimaging plays a key role in diagnosis.
View Article and Find Full Text PDFMedication-Induced Lymphomatoid Granulomatosis Presenting as a Solitary Periocular Cutaneous Lesion.
Ophthalmic Plast Reconstr Surg
December 2024
Department of Ophthalmology & Visual Sciences.
Lymphomatoid granulomatosis, a rare lymphoproliferative disorder, was previously defined by categorical pulmonary involvement with possible invasion into the skin, central nervous system, liver, and kidneys. However, recent reports have documented confirmed cases of lymphomatoid granulomatosis without lung involvement. Here, the authors describe a 70-year-old male with rheumatoid arthritis on methotrexate who presented with an ulcerating lesion on the right lower eyelid, initially suspicious for a basal cell carcinoma.
View Article and Find Full Text PDFAn Update on EBV-related Cutaneous Lymphoproliferative Disorders: a Systematic Review.
Actas Dermosifiliogr
November 2024
Universidad de Zaragoza, Zaragoza, España; Servicio de Anatomía Patológica, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Epstein Barr virus (EBV) positive B lymphoproliferative disorders (LPD) with cutaneous involvement include a series of rare entities that go from indolent processes to aggressive lymphomas. B-cell EBV+ LPD mainly affect immunocompromised patients while T-cell EBV+ LPD are more prevalent in specific geographic regions such as Asia, Central America, and South America. Since the latest WHO-EORTC classification of cutaneous lymphomas in 2018, significant changes have been included in the new classifications of hematological malignancies.
View Article and Find Full Text PDFIsolated central nervous system lymphomatoid granulomatosis in an older adult patient with systematic lupus erythematosus: A case report.
Mod Rheumatol Case Rep
October 2024
Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Aichi, Japan.
Lymphomatoid granulomatosis (LYG) is a rare, T-cell-rich Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative systemic disease. Only a few cases of LYG have been described in patients with autoimmune disorders, with only one case described in a patient with systemic lupus erythematosus (SLE). However, no cases of isolated central nervous system (CNS)-LYG have been reported in patients with autoimmune diseases.
View Article and Find Full Text PDFEpstein-Barr virus-related lymphoproliferative disorders of the skin.
Dermatol Reports
May 2024
Anatomic Pathology and Cytopathology Unit, G. Pascale Foundation National Cancer Institute IRCCS, Naples, Italy.
Article Synopsis
- - Epstein Barr Virus (EBV) is linked to various cancers, including nasopharyngeal and gastric carcinomas, as well as different types of lymphomas that can range from mild to severe illnesses.
- - The review highlights skin-related disorders associated with EBV, such as EBV-positive mucocutaneous ulcer, lymphomatoid granulomatosis, and several lymphomas including diffuse large B cell lymphoma and plasmablastic lymphoma.
- - Due to the rarity of these skin conditions, a multidisciplinary approach and referrals to specialized care centers are recommended for proper management and treatment.
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