Aim: To synthesize and study the antithrombotic activity of NO-donating aspirin derivatives.
Methods: Furoxans and nitrates were incorporated to aspirin via antioxidant ferulic acid as a linker, and the target compounds were screened for in vitro and in vivo inhibitory activities of platelet aggregation, and for inhibitory effect on A-V hypass thromhosis in rats.
Results: Fourteen novel compounds I(1-14), were synthesized and their structures were confirmed Iy MS, IR, 1H NMR and elemental analysis. Biological screening results demonstrated that some tested compounds exhibited potential antithrombotic activ it.
Conclusion: Acetylsalicyl ferulic acid-coupling furoxans and nitrates might he used as a lead for further study.
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