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HPTLC-Bioautography-MS-Guided Strategy for the Detection of Phthalides With Antimicrobial and Antioxidant Activities From Ligusticum chuanxiong Essential Oil.
Phytochem Anal
January 2025
Department of Pharmacy, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Introduction: Antimicrobial resistance and free radical-mediated oxidative stress and inflammation involved in many pathological processes have become treatment challenges. One strategy is to search for antimicrobial and antioxidant ingredients from natural aromatic plants. This study established a rapid and high-throughput effect-component analysis method to screen active ingredients from Ligusticum chuanxiong essential oil (CXEO).
View Article and Find Full Text PDFChinmedomics strategy for elucidating the effects and effective constituents of Danggui Buxue Decoction in treating blood deficiency syndrome.
Front Mol Biosci
March 2024
State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Introduction: Danggui Buxue Decoction (DBD) is a clinically proven, effective, classical traditional Chinese medicine (TCM) formula for treating blood deficiency syndrome (BDS). However, its effects and effective constituents in the treatment of BDS remain unclear, limiting precise clinical therapy and quality control. This study aimed to accurately evaluate the effects of DBD and identify its effective constituents and quality markers.
View Article and Find Full Text PDFDiscovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from and Its Bioinspired Total Synthesis.
ACS Cent Sci
March 2024
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.
, commonly known as Dong Quai in Europe and America and as Dang-gui in China, is a medicinal plant widely utilized for the prevention and treatment of osteoporosis. In this study, we report the discovery of a new category of phthalide from , namely falcarinphthalides A and B ( and ), which contains two fragments, (3,8)-falcarindiol () and ()-ligustilide (). Falcarinphthalides A and B ( and ) represent two unprecedented carbon skeletons of phthalide in natural products, and their antiosteoporotic activities were evaluated.
View Article and Find Full Text PDFAntiadhesive phthalides from Apium graveolens fruits against uropathogenic E. coli.
J Ethnopharmacol
June 2019
University of Münster, Institute of Pharmaceutical Biology and Phytochemistry, Münster, Germany. Electronic address:
Ethnopharmacological Relevance: Fruits of Apium graveolens (celery) are used traditionally in Persian and European medicine for the treatment of uncomplicated urinary tract infections.
Aim Of The Study: The study aimed at identifying potential antiadhesive compounds from celery extracts to provide strategies for improved standardization of the herbal material.
Materials And Methods: Decoction, hydroalcoholic and acetone extracts were prepared from celery fruits.
Antimycobacterials from lovage root (Ligusticum officinale Koch).
Phytother Res
July 2013
Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
The n-hexane extract of Lovage root was found to significantly inhibit the growth of both Mycobacterium smegmatis mc²155 and Mycobacterium bovis BCG, and therefore a bioassay-guided isolation strategy was undertaken. (Z)-Ligustilide, (Z)-3-butylidenephthalide, (E)-3-butylidenephthalide, 3-butylphthalide, α-prethapsenol, falcarindiol, levistolide A, psoralen and bergapten were isolated by chromatographic techniques, characterized by NMR spectroscopy and MS, and evaluated for their growth inhibition activity against Mycobacterium tuberculosis H₃₇Rv using the whole-cell phenotypic spot culture growth inhibition assay (SPOTi). Cytotoxicity against RAW 264.
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