[Peculiarities of lipid metabolism in pregnant patients with chronic cholecystitis].

Chronic diseases of gall-bladder are found in 3-5% of pregnancies. Lipid metabolism also undergoes essential changes. The aim of our investigation was to study the peculiarities of lipid metabolism in pregnant patients with chronic cholecystitis. 33 pregnant patients with chronic cholecystitis have been investigated. The duration of pregnancy was 36,8+/-0,4 weeks. Control group consisted of 30 practically healthy pregnant patients in the third trimester. All parameters of lipid metabolism have been determined by biochemical analysis. The parameters of lipid metabolism became significantly impaired in patients with chronic cholecystitis in comparison with controls. They revealed significant both direct and inverse correlations with sex hormones. Obtained results point the organism adaptive mechanisms expressed in the increase of antiatherogenic fraction of total cholesterol; also the influence of sex hormones. In pregnancy, physiological dyslipidemia increases, which is metabolic basis for the development of "prestage" of gall-stone--cholestasis of gall-bladder.