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Promoting trans patient autonomy in surgical preparation for phalloplasty and metoidioplasty: results from a community-based cross-sectional survey and implications for preoperative assessments.
BMC Med Ethics
December 2024
School of Public Health and Social Policy, Faculty of Human and Social Development, University of Victoria, Victoria, BC, Canada.
Background: Some transgender and nonbinary people undergo phalloplasty and/or metoidioplasty as part of their medical transition process. Across surgical disciplines, a variety of resources are used to assist patients who are preparing for surgeries, including educational materials, workshops, peer support, and lifestyle changes. For gender-affirming surgeries, patients undergoing assessments to discern whether they are ready to undergo the surgery, and to assist them in achieving preparedness when needed.
View Article and Find Full Text PDFDysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons.
Am J Physiol Cell Physiol
December 2024
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway.
Amyotrophic lateral sclerosis (ALS) is characterized by dysfunction and loss of upper and lower motor neurons. Several studies have identified structural and functional alterations in the motor neurons before the manifestation of symptoms, yet the underlying cause of such alterations and how they contribute to the progressive degeneration of affected motor neuron networks remain unclear. Importantly, the short and long-term spatiotemporal dynamics of neuronal network activity make it challenging to discern how ALS-related network reconfigurations emerge and evolve.
View Article and Find Full Text PDFTo kill or to piggyback: Switching of viral lysis-lysogeny strategies depending on host dynamics.
Sci Total Environ
December 2024
Archaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen 518055, PR China. Electronic address:
Viruses wield significant influence over microbial communities and ecosystem function in marine environments. However, the selection of viral life strategies and their impacts on microbial communities remains enigmatic. In this study, we utilized a large-scale macrocosm, established using water samples from a marine coastal region, to enable community-level investigation.
View Article and Find Full Text PDFPhage biocontrol in water treatment and reuse systems: a nascent field with significant innovation opportunities.
Curr Opin Biotechnol
December 2024
Sentinel Environmental, Houston, Texas 77082, United States; Department of Civil and Environmental Engineering, and Rice Water Institute, Rice University, Houston, Texas 77005, United States.
While the use of phages in the food and biomedical sectors occurs commercially, their application in the water sector is less common and is typically demonstrated at a lower technological readiness level. This is so despite the potential that phages have to enhance the control of problematic bacteria (including pathogens) and protect infrastructure within the water sector. Fulfilling the great potential of this nascent field requires more research and development.
View Article and Find Full Text PDFMachine and deep learning algorithms for sentiment analysis during COVID-19: A vision to create fake news resistant society.
PLoS One
December 2024
Centro de Investigación en Computación (CIC), Instituto Politécnico Nacional, Ciudad de México, México.
Informal education via social media plays a crucial role in modern learning, offering self-directed and community-driven opportunities to gain knowledge, skills, and attitudes beyond traditional educational settings. These platforms provide access to a broad range of learning materials, such as tutorials, blogs, forums, and interactive content, making education more accessible and tailored to individual interests and needs. However, challenges like information overload and the spread of misinformation highlight the importance of digital literacy in ensuring users can critically evaluate the credibility of information.
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