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Grade III of Blunt Thoracic Aortic Injury and Duodenal Perforation due to Multiple Trauma; Which Is Priority? A Case Report.
Clin Case Rep
January 2025
Department of General Surgery, Shahid Modarres Hospital Shahid Beheshti University of Medical Sciences Tehran Iran.
Perforation of the duodenum after trauma has a low incidence and its coincidence with BTAI is very rare. The clinical condition of the patient is very important for deciding the treatment priority. In this patient, considering the stable condition and degree of aorta injury, we chose TEVAR before laparotomy.
View Article and Find Full Text PDFThe interdependent hemodynamic influence between abdominal aortic aneurysm and renal artery stenosis.
Sci Rep
December 2024
Department of Biomedical Engineering, National University of Singapore, Block E7 #06-02, 15 Kent Ridge Cres, Singapore, 119276, Singapore.
Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide with abdominal aortic aneurysm (AAA) and renal artery stenosis (RAS) standing out as significant contributors to the vascular pathology spectrum. While these conditions have traditionally been approached as distinct entities, emerging evidence suggests a compelling interdependent relationship between AAA and RAS, challenging the conventional siloed understanding. The confluence of AAA and RAS represents a complex interplay within the cardiovascular system, one that is often overlooked in clinical practice and research.
View Article and Find Full Text PDFFumarate Hydratase-Deficient Renal Cell Carcinoma With Paraganglioma Detected on 18F-FDG PET/CT.
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December 2024
Nuclear Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China.
We report FDG PET/CT findings of fumarate hydratase-deficient renal cell carcinoma coincidence with para-aortic paraganglioma in a 27-year-old man. He presented with painless gross hematuria for 3 days. CT identified an enhancing lesion in the left kidney, suggestive of a tumor.
View Article and Find Full Text PDFPCSK9 promotes vascular neointimal hyperplasia through non-lipid regulation of vascular smooth muscle cell proliferation, migration, and autophagy.
Biochem Biophys Res Commun
January 2025
Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China; Hebei Key Laboratory of Heart and Metabolism, Shijiazhuang, 050031, Hebei, China. Electronic address:
We aim to explore the impact of Proprotein convertase subtilisin-kexin type 9 (PCSK9) and its inhibitor evolocumab on neointimal hyperplasia. Wild type and PCSK9 knockout (PCSK9) mice were subjected to ligation of the common carotid artery, with or without subcutaneous injection of evolocumab. Mouse aortic vascular smooth muscle (MOVAS) cells were pretreated with evolocumab or under siRNA-mediated suppression of PCSK9, and then exposed to platelet-derived growth factor type BB(PDGF-BB), a major promoter of MOVAS transformation to a proliferative phenotype.
View Article and Find Full Text PDFDevelopment of an automated region-of-interest-setting method based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods.
Asia Ocean J Nucl Med Biol
January 2024
Department of Medical Radiation Sciences, Faculty of Life Science, Kumamoto University, Japan.
Objectives: A simple noninvasive microsphere (SIMS) method using I-IMP and an improved brain uptake ratio (IBUR) method using Tc-ECD for the quantitative measurement of regional cerebral blood flow have been recently reported. The input functions of these methods were determined using the administered dose, which was obtained by analyzing the time activity curve of the pulmonary artery (PA) for SIMS and the ascending aorta (AAo) for the IBUR methods for dynamic chest images. If the PA and AAo regions of interest (ROIs) can be determined using deep convolutional neural networks (DCNN) for segmentation, the accuracy of these ROI-setting methods can be improved through simple analytical operations to ensure repeatability and reproducibility.
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