Bazex syndrome, or paraneoplastic acrokeratosis, is a rare psoriasis-like paraneoplastic skin disease, characterized by erythema and scaling, which is accompanied by hyperkeratotic lesions. The tumors most frequently associated with Bazex syndrome are squamous cell carcinomas of the upper respiratory and digestive tracts, whereas lung cancers, particularly adenocarcinomas, are rarely associated. We present a case in which both pulmonary adenocarcinoma and Bazex syndrome were present.
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Acrokeratosis paraneoplastica (Basex syndrome) with trachyonychia preceding the diagnosis of squamous cell carcinoma of the lung.
Dermatol Online J
April 2024
Department of Dermatology, Tulane University, New Orleans USA Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo USA.
Acrokeratosis paraneoplastica (Basex syndrome) is a rare paraneoplastic condition hallmarked by psoriasiform lesion development on acral surfaces, most often related to an underlying squamous cell carcinoma. Patients may also present with nail plate changes. Successful management of this condition can be accomplished by treating the underlying malignancy.
View Article and Find Full Text PDF[Palmoplantar dermatoses: Diagnostic approach in primary care].
Semergen
November 2024
Servicio de Dermatología/UNACESS, Hospital Clínico San Borja Arriarán, Santiago, Chile; Departamento de Dermatología, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address:
Article Synopsis
- This article discusses the diagnostic difficulties faced by primary health care providers when dealing with palmoplantar dermatoses (PPD), which are common skin conditions affecting the palms and soles.
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Whole genome sequencing revealing Xq26.1 intergenic duplications associated with Bazex-Dupré-Christol syndrome in a Chinese family.
J Eur Acad Dermatol Venereol
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Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review.
Heliyon
March 2024
Department of Legal Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.
Article Synopsis
- The skin can indicate internal diseases, with Bazex syndrome being a specific condition that shows erythematous hyperkeratosis and yellowish scales on palms and soles.
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[Bazex syndrome: a rare paraneoplastic disease].
Medicina (B Aires)
January 2024
Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Bazex syndrome is a paraneoplastic disorder most commonly linked to squamous cell carcinomas of the upper aerodigestive tract, followed by lung cancer and other malignancies. It manifests through three stages of skin involvement that mirror the tumor's progression. Remarkably, skin lesions precede tumor symptoms or diagnosis in two-thirds of cases, underscoring the crucial role of suspecting this condition as it can promptly reveal an underlying neoplasm.
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