AI Article Synopsis
- A new compound, chloro-depsidone (1), and five known compounds were isolated from the lichen Ochrolechia parella, with their structures analyzed using spectroscopic techniques.
- The study compared two specimens of the lichen grown in different light conditions, revealing that variolaric acid (2) was the predominant compound, particularly in the shaded specimen, while the new compound parellin (1) thrived in low light.
- Cytotoxic activities of variolaric acid (2), alpha-alectoronic acid (4), and ergosterol peroxide (6) were tested against B16 melanoma cells to assess their potential medicinal properties.
Article Abstract
A new chloro-depsidone (1) and five known compounds, variolaric acid (2), lecanoric acid (3), alpha-alectoronic acid (4), atranorin (5), and ergosterol peroxide (6), have been isolated from the lichen Ochrolechia parella. The structure of compound 1 was elucidated by spectroscopic analysis. Additionally, the tautomeric equilibrium of compound 4 was investigated. In the present study, two specimens of this lichen, growing under different light conditions, were analyzed. The major compound in both samples was found to be 2, but the amount of this metabolite was significantly higher in the shaded specimen (0.76% w/w). The new compound parellin (1) predominated in the specimen grown under shady conditions, while atranorin (5) was found only in the sunlit specimen. The cytotoxic activities of 2, 4, and 6 against B16 melanoma cells were evaluated.
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| http://dx.doi.org/10.1021/np060561p | DOI Listing |
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