The authors analysed the results of controlled treatment by three methods of patients in the 1st or 2nd phase of SSPE in a randomized group. The groups received: I. Propionibacterium granulosum KP-45 (interferon inducer) + isoprinosine, II--TFX (thymus extract) + isoprinosine, III--only isoprinosine. In all groups the treatment was continued during 6 months. The analysis of the clinical results of these methods failed to demonstrate a statistically significant superiority of any of these methods (among others, due to small number of cases) but an evident statistical tendency was revealed suggesting a better effectiveness of combined treatment (immunostimulator + isoprinosine) in relation to treatment with isoprinosine only. The final evaluation of the results requires further observations of these patients.
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Often ill people are, first of all, patients with recurrent infectious and inflammatory diseases of the upper respiratory tract (URT). They put a significant financial burden on the healthcare system. The leading etiological factors of recurrent inflammatory diseases of URT, in addition to pathogenic bacterial microflora, are viral agents (viruses of the viral respiratory infections group, herpes viruses).
View Article and Find Full Text PDFContemporary Treatment Practices for Subacute Sclerosing Panencephalitis: A Nationwide Survey Among Adult and Pediatric Neurologists in India.
Ann Indian Acad Neurol
November 2024
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- SSPE is a rare, progressive disorder caused by a lingering mutant measles virus in the brain, with unclear treatment strategies among neurologists.
- A survey of 298 Indian neurologists revealed insights into their management practices, showing varied preferences for therapies such as Isoprinosine and valproate.
- There is a significant gap in follow-up care for SSPE patients and an urgent need for clearer treatment guidelines to improve patient outcomes.
Substantial Improvement in a Patient with Subacute Sclerosing Panencephalitis: An Unusual Case Report.
Tremor Other Hyperkinet Mov (N Y)
November 2024
Department of Neurology, King George's Medical University, Lucknow, India.
Background: Subacute Sclerosing Panencephalitis (SSPE) is a fatal disorder marked by gradual cognitive and motor deterioration, leading to death typically within 1-3 years.
Case Report: A 20-year-old woman with progressive abnormal behaviour, forgetfulness, and involuntary movements showed significant improvement after treatment with interferon and isoprinosine. Initially severely cognitively impaired and dependent, she regained independence and demonstrated marked cognitive enhancement, her MMSE improved from 15 to 28 and reduced myoclonus.
The Rare Case Presentation of Adult-Onset Fulminant Subacute Sclerosing Panencephalitis in a 24-Year-Old Male.
Cureus
September 2024
Child Health Nursing, Smt. Radhikabai Meghe Memorial College of Nursing, Wardha, IND.
Article Synopsis
- * There is no definitive cure for SSPE, but a treatment combining intrathecal interferon-α (IFN-α) and oral isoprinosine has shown effectiveness.
- * A case study of a 24-year-old male with spastic seizure epilepsy highlighted the diagnosis of SSPE through increased measles antibodies in cerebrospinal fluid, abnormal EEG readings, and distinctive MRI findings.
A Rare Case of Subacute Sclerosing Panencephalitis in an Immunized Patient.
Cureus
June 2024
Pediatrics, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
This study presents a case of subacute sclerosing panencephalitis (SSPE), a rare neurologic disorder characterized by brain inflammation, typically triggered by measles virus reactivation or an abnormal immune response to it. This case involves a five-year-old male child with persistent fever, declining motor function, excessive sleepiness, and myoclonic jerks. MRI indicated potential ischemic changes or encephalitis, while electroencephalography showed SSPE-consistent patterns.
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