PAK-in' up cGMP for the move.

Cell

MGH Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

Published: January 2007

Although guanylyl cyclases have been implicated in cell migration, how they are activated to promote cell motility is unknown. In this issue, report direct communication between guanylyl cyclases and the Rac-p21-activated kinase (PAK) signaling pathway--which is essential for cell migration--to promote cell motility, through allosteric activation of guanylyl cyclases by autophosphorylated PAK.

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http://dx.doi.org/10.1016/j.cell.2007.01.002DOI Listing

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