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Efficacy of Early Goal-Directed Therapy in Septic Shock Management: A Systematic Review.
Cureus
November 2024
Obstetrics and Gynecology, Private Clinic "Yana Alexandr", Sana'a, YEM.
Septic shock is a serious and life-threatening illness marked by potentially fatal and metabolic abnormalities, leading to high mortality rates in adult patients. Early goal-directed therapy (EGDT) was introduced as a systematic approach to manage septic shock through early, protocol-based hemodynamic optimization to improve outcomes. This systematic review aims to evaluate the efficacy of EGDT in managing adult patients with septic shock.
View Article and Find Full Text PDFWhat is the role of parenteral nutrition in the management of the patient with severe acute pancreatitis?
Nutr Clin Pract
December 2024
Department of Surgery, Oregon Health Sciences University, Portland, Oregon, USA.
Severe acute pancreatitis often presents as a complex critical illness associated with a high rate of infectious morbidity, multiple organ failure, and in-hospital mortality. Breakdown of gut barrier defenses, dysbiosis of intestinal microbiota, and exaggerated immune responses dictate that early enteral nutrition (EN) is preferred over parenteral nutrition (PN) as the primary route of nutrition therapy. EN, however, is not feasible in all cases because of intolerance, risk of complications, or a direct contraindication to enteral feeding.
View Article and Find Full Text PDFIntraoperative goal-directed hemodynamic therapy targeting both arterial pressure and flow parameters using uncalibrated pulse contour techniques: A meta-analysis of randomized controlled trials.
Rev Esp Anestesiol Reanim (Engl Ed)
December 2024
Fluid Therapy and Hemodynamic Monitoring Group of the Spanish Society of Anesthesiology and Critical Care, Madrid, Spain; Hospital Universitario Puerto Real, Cádiz, Spain.
Background: Goal-directed haemodynamic therapy (GDHT) aims to optimize haemodynamic variables. However, its effectiveness in reducing postoperative complications in major abdominal surgery, particularly when targeting both arterial pressure and flow variables, remains unclear. This meta-analysis addresses this by evaluating GDHT using uncalibrated pulse contour (uPC) methods.
View Article and Find Full Text PDFImplementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial.
PLOS Glob Public Health
December 2024
The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia.
The third, stepped-wedge, cluster-randomized, Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3), has shown that a goal-directed multi-faceted Care Bundle incorporating protocols for the management of physiological variables was safe and effective for improving functional recovery in a broad range of patients with acute intracerebral hemorrhage (ICH). The INTERACT3 Care Bundle included time- and target-based protocols for the management of early intensive lowering of systolic blood pressure (SBP, target <140mmHg), glucose control (target 6.1-7.
View Article and Find Full Text PDFUtilizing movement-related potentials to monitor cognitive rehabilitation in individuals with central nervous system disorders: A review.
Int J Psychophysiol
December 2024
Department of Biological and Health Psychology, Faculty of Psychology, Universidad Autónoma de Madrid, Spain.
In current neuroscience, there is a pressing need to evaluate the effectiveness of treatments for motor and cognitive disorders. In addition, there is a gap in the literature on assessing this type of rehabilitation. This review proposes using Movement-Related Potentials (MRPs) as a relevant marker for such evaluations.
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