AI Article Synopsis
- The chiral bisnaphthopyrone natural product nigerone was synthesized enantioselectively through a detailed chemical process.
- A critical part of the synthesis involved an eight-step isomerization to achieve nigerone.
- The isomerization precursor was created using asymmetric oxidative biaryl coupling with a specific 1,5-diaza-cis-decalin copper catalyst.
Article Abstract
[reaction: see text] An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone is reported. The key step was an eight-step isomerization process to form the final natural product. The isomerization precursor was constructed via asymmetric oxidative biaryl coupling of an advanced intermediate with a 1,5-diaza-cis-decalin copper catalyst.
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| http://dx.doi.org/10.1021/ol062468y | DOI Listing |
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text] enantioselective
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