Gradual corrosion of stainless steel electrospray emitters under conditions of normal use generates surface irregularities that can promote electrical discharge. The increased emission current affects the electrochemical reactions associated with the spray process. When sampling the peptide Abeta(1-40), this is manifest by oxidation of methionine at position 35 to methionine sulfoxide. The resultant mass shift and reduced sensitivity can adversely affect H/D exchange experiments. These effects can be avoided by adding a redox buffer or (preferably) by repolishing the emitter, especially to a rounded geometry.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597585 | PMC |
| http://dx.doi.org/10.1021/ac061743r | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-Resolution Free-Breathing Chemical-Shift-Encoded MRI for Characterizing Lymph Nodes in the Upper Abdomen.
Invest Radiol
January 2025
From the Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (I.T.M., M.C.M., S.Y., R.v.d.E., A.V., E.J.S., J.J.H., T.W.J.S.); and Department of Radiology, NYU Langone Health, New York, NY (T.K.B.).
Objectives: Accurate lymph node (LN) staging is crucial for managing upper abdominal cancers. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging effectively distinguishes healthy and metastatic LNs through fat/water and -weighted imaging. However, respiratory motion artifacts complicate detection of abdominal LNs.
View Article and Find Full Text PDFLC-ESI-MS/MS is a preferred method for detecting and identifying metabolites, including those that are unpredictable from the genome, especially in basal metazoans like Cnidaria, which diverged earlier than bilaterians and whose metabolism is poorly understood. However, the unexpected appearance of a "ghost peak" for dopamine, which exhibited the same m/z value and MS/MS product ion spectrum during an analysis of Nematostella vectensis, a model cnidarian, complicated its accurate identification. Understanding the mechanism by which "ghost peaks" appear is crucial to accurately identify the monoamine repertoire in early animals so as to avoid misassignments.
View Article and Find Full Text PDFAbsorbable Haemostatic Artefacts as a Diagnostic Challenge in Postoperative Follow-Up After Oncological Resection in Head and Neck Tumours: Systematic Review of Current Literature and Two Case Reports.
Diagnostics (Basel)
November 2024
Head and Neck Department, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Aristide Stefani 1, 37126 Verona, Italy.
This article aims to define the clinical, radiological, and pathological characteristics of non-resorbed oxidised cellulose-induced pseudotumours to raise awareness among surgeons and radiologists, to prevent misdiagnosis, and avoid unnecessary invasive procedures and delays in adjuvant oncological treatments. A systematic review of oxidised resorbable cellulose (ORC)-induced pseudotumours of the head and neck was conducted following PRISMA 2020 guidelines. Articles were retrieved from PubMed, Scopus, Cochrane, and Web of Science.
View Article and Find Full Text PDFEvaluation of aortic stent endoleaks in the renally impaired patient with ferumoxytol-enhanced MR angiography.
Clin Imaging
February 2025
Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:
Purpose: To evaluate ferumoxytol-enhanced magnetic resonance angiography (FE-MRA) for assessment of endoleaks in patients with abdominal aortic aneurysms (AAA) and chronic kidney disease (CKD) status post endovascular aneurysm repair (EVAR).
Methods: Of 1854 patients who underwent FE-MRA at a single institution between 03/21/2014 and 08/21/2023, 21 patients with a history of AAA and CKD status post EVAR were retrospectively identified (IRB #13-001341). Multiplanar pre- and post-contrast HASTE, T1-VIBE, and high-resolution breath-held 3D MRA sequences were obtained, where a dose of 4 mg/kg of Ferumoxytol was infused over six minutes.
[Fundamental Study on Artifacts and Displacement Force of Cosmetics Such as Eye Makeup in MRI Examinations].
Nihon Hoshasen Gijutsu Gakkai Zasshi
December 2024
Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University.
Purpose: In MRI examinations, makeup cosmetics may cause image artifacts or be adsorbed by a static magnetic field. However, there are no reports on each cosmetic material ingredient. The purpose of this study was to evaluate the displacement force and image artifacts caused by cosmetic ingredients and to clarify the cosmetic ingredients that need to be removed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!