ALA-PDT is a safe, well-tolerated, and effective treatment for many dermatologic conditions. Current data most strongly support its use in the treatment of actinic damage, but further investigation into alternative uses continues. Current efficacy is limited primarily by the depth of penetration of the photosensitizing agent and the activating light source. Even with this limitation, the potential applications of PDT are numerous. As new technology is developed to overcome current restraints, the future of PDT is wide open.
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http://dx.doi.org/10.1016/j.yadr.2006.09.008 | DOI Listing |
J Colloid Interface Sci
March 2025
School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China. Electronic address:
Photodynamic (PDT) and chemodynamic therapies (CDT) relying on reactive oxygen species-mediated treatments mainly face various challenges of hypoxia, endogenous hydrogen peroxide (HO) deficiency, and glutathione (GSH) overexpression in the tumor microenvironment. Herein, we propose a novel strategy using a core-shell structured nanocomposite, UCNP@mSiO@5-ALA-CaO-Cu(UA@CC). The strategy centers on upconverting NPs and then utilizes mesoporous silica loaded with 5-aminolevulinic acid (5-ALA) to maximize the enrichment of protoporphyrin IX (Pph IX), an intra-tumor photosensitizer.
View Article and Find Full Text PDFJ Photochem Photobiol B
March 2025
Graduate Program in Pharmaceutical Sciences, Center for Biological and Health Sciences, State University of Paraíba, Campina Grande, Paraíba, Brazil. Electronic address:
Antimicrobial photodynamic therapy (aPDT) is based on oxidative photochemical reactions and can be used against vulvovaginal candidiasis (VVC), caused by Candida albicans. This can be achieved by incorporating phthalocyanine (PC) into a polymer-matrix nanocomposite based on nanostructured lipid carriers (NLC) ureasil-polyether (UPEO), which allows them to be molded into a vaginal ring. The aim was to evaluate the aPDT of PC-NLC-UPEO rings against C.
View Article and Find Full Text PDFInt Ophthalmol
March 2025
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Purpose: This study aims to analyze the vision-related quality of life (vr-QoL) in keratoconus (KC) patients after corneal crosslinking (CXL).
Methods: A prospective clinical study was conducted, wherein 41 patients underwent assessment using the "National Eye Institute Visual Functioning Questionnaire" (NEI-25) and the "Keratoconus Outcomes Research Questionnaire" (KORQ) to evaluate vr-QoL, along with the examination of morphology and functional parameters before CXL, and at three and six months post-treatment. Rasch analyses were used to verify the measurement precision of the KORQ with our study population.
Inflamm Res
March 2025
Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Objective: Ferroptosis is a non-apoptotic cell death mechanism driven by reactive oxygen species (ROS) and iron. Its significance in inflammatory arthritis is well-established, but its role in rheumatoid arthritis (RA) remains uncertain. This study aimed to clarify the mechanisms through which curcumin-mediated photodynamic therapy (CUR-PDT) triggers ferroptosis in RA fibroblast-like synoviocytes (FLSs).
View Article and Find Full Text PDFNanoscale
March 2025
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, P. R. China.
Multimodal combined therapy constitutes an ideal strategy for the treatment of primary tumors and the suppression of distant metastatic tumors. In this study, a 4T1 cell membrane-coated UCNPs@ZnMnS (TUC@ZMS) nanoplatform is designed for synergistic photodynamic (PDT), chemodynamic (CDT), gas, and immune-based cancer therapy. The 4T1 cell membrane coating enhances tumor-targeting specificity, while TUC@ZMS, under 980 nm near-infrared (NIR) light activation, generates singlet oxygen (O) for PDT and induces reactive oxygen species (ROS) CDT to trigger tumor cell apoptosis.
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