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| http://dx.doi.org/10.1093/genetics/15.1.55 | DOI Listing |
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Defining a novel DYRK1A-gp130/IL-6R-pSTAT axis that regulates Th17 differentiation.
Immunohorizons
January 2025
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, United States.
Dysregulated differentiation of naïve CD4+ T cells into T helper 17 (Th17) cells is likely a key factor predisposing to many autoimmune diseases. Therefore, better understanding how Th17 differentiation is regulated is essential to identify novel therapeutic targets and strategies to identify individuals at high risk of developing autoimmunity. Here, we extend our prior work using chemical inhibitors to provide mechanistic insight into a novel regulator of Th17 differentiation, the kinase dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).
View Article and Find Full Text PDFImpact of Gene Knockout on Cell Aggregation in Suspension Culture.
BioTech (Basel)
January 2025
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, pr. Lavrentieva 10, Novosibirsk 630090, Russia.
The development of efficient producers of recombinant pharmaceuticals based on plant cell suspension cultures is a pressing challenge in modern applied science. A primary limitation of plant cell cultures is their relatively low yield of the target protein. One strategy to enhance culture productivity involves reducing cell aggregation.
View Article and Find Full Text PDFBimodal Patterns of Locomotor Activity and Sleep in : A Model for Their Simulation.
Nat Sci Sleep
January 2025
Department of Insect Genetics, Institute of Cytology and Genetics of the Siberian Branch, the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Purpose: Two previously proposed modelling approaches to explain the bimodal pattern of activity and/or sleep in are based on 1) the concept of morning and evening oscillators underlying the peaks of activity in the morning and evening, respectively, and 2) the concept of two cycles of buildup and decay of sleep pressure, gated only by the circadian oscillator. Previously, we simulated 24-h alertness-sleepiness curves in humans using a model postulating the circadian modulation of the buildup and decay phases of two (wake and sleep) homeostatic processes. Here, we tested whether a similar model could be applied to simulate the bimodal 24-h rhythm of fly locomotor activity and sleep.
View Article and Find Full Text PDFGenetic diversity leads to differential inflammatory responses to cigarette smoke in mice.
Physiol Rep
January 2025
Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
The use of genetically diverse mouse models offers a more accurate reflection of human genetic variability, improving the translatability of findings to heterogeneous human populations. This approach is particularly valuable in understanding diverse immune responses to disease by environmental exposures. This study investigates the inflammatory responses to acute exposures to mainstream cigarette smoke (CS) and environmental tobacco smoke (ETS) in two genetically diverse mouse strains, CC002/UncJ (UNC) & Diversity Outbred (J:DO).
View Article and Find Full Text PDFUnveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex.
Cell Commun Signal
January 2025
Department of Life Sciences, Institute of Genome Sciences, National Yang Ming Chiao Tung University, 155 Li-Nong Street, Section 2, Beitou, Taipei, 112, Taiwan.
Background: TGF-β1 is the most abundant cytokine in bone, in which it serves as a vital factor to interdict adipogenesis and osteogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, how TGF-β1 concurrently manipulates differentiation into these two distinct lineages remains elusive.
Methods: Treatments with ligands or inhibitors followed by biochemical characterization, reporter assay, quantitative PCR and induced differentiation were applied to MSC line or primary BM-MSCs for signaling dissection.
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