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Achieving Ultrabright NIR-II Nanofluorophore for In Vivo Imaging by Inhibiting H-Aggregates Formation.
Chemistry
December 2024
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830054, China.
Small molecules with an acceptor-donor-acceptor (A-D-A) structure, featuring a fused-ring core as the donor and two electron-withdrawing end groups as acceptor units, represent a potential option for NIR-II fluorophores, benefiting from their narrow bandgaps, superior light-harvesting capabilities, and exceptional photostabilities. However, their planar conformations predispose them to forming H-aggregates during self-assembly, leading to significantly reduced fluorescence quantum yield (QY) of the resulting nanofluorophores. Herein, we report a small molecule, PF8CN, with a terminal unit-A-D-A-terminal unit structure.
View Article and Find Full Text PDFUltrabright NIR-II Emissive Polymer Dots for Metastatic Ovarian Cancer Detection.
Adv Sci (Weinh)
February 2021
Intraoperative diagnosis of metastatic tumors is of significant importance to the treatment of ovarian cancer. NIR-II fluorescence imaging holds great promise for facile detection of tumor in situ with high sensitivity and resolution. Herein, a kind of NIR-II fluorescent polymer dots (NIR-II Pdots) with high brightness is developed for real-time detection of metastatic ovarian cancer via NIR-II fluorescence imaging.
View Article and Find Full Text PDFUltrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.
Mater Today (Kidlington)
March 2019
Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
Cellulose acetate (CA), viscose, or artificial silk are biocompatible human-benign derivatives of cellulose, one of the most abundant biopolymers on earth. While various optical materials have been developed from CA, optical CA nanomaterials are nonexistent. Here we report on the assembly of a new family of extremely bright fluorescent CA nanoparticles (CA-dots), which are fully suitable for in vivo imaging / targeting applications.
View Article and Find Full Text PDFAqueous Synthesis of Multi-Carbon Dot Cross-Linked Polyethyleneimine Particles with Enhanced Photoluminescent Properties.
Macromol Rapid Commun
May 2019
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, P. R. China.
Heavy-metal-free fluorescent nanoparticles with high photostability and low toxicity are highly desirable as imaging probes for biological applications. Here, a novel synthetic strategy to prepare ultrabright multi-carbon dot cross-linked PEI particles, namely CDs@PEI, through self-assembly of hydrophobically modified PEI and in situ generations of carbon dots within residual monomer-swollen micelles is reported. The resulting particles consist of numerous carbon dots, which are individually and homogeneously embedded within the PEI network, and have an average hydrodynamic diameter of approximately 100 nm with ζ-potential above +35 mV.
View Article and Find Full Text PDFFacile synthesis of AIE-active amphiphilic polymers: Self-assembly and biological imaging applications.
Mater Sci Eng C Mater Biol Appl
September 2016
Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, China.
In this work, we reported a rather facile method for fabrication of ultrabright, well dispersible and biocompatible fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) properties through combination of esterification and ring-opening reaction. The hydroxyl groups of Pluronic F127 was first reacted with the chloride of trimellitic anhydride chloride (TMAC), and its anhydride groups were further reacted with the amino groups of amino-terminated AIE dye (PhNH2) through ring-opening reaction. The optical properties, biocompatibility as well as cell uptake behavior of these obtained AIE-active nanoparticles (F127-TMAC-PhNH2 FONs) were examined by a series of characterization techniques and assays.
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