Human platelet aggregation inhibition by coumarins isolated from Feroniella lucida roots extract was investigated. Of 11 coumarins examined, feroniellin B highly inhibited platelet aggregation induced by ADP with an IC(50) value of 0.287 mm while the standard drug ibuprofen displayed this inhibition with an IC(50) value of 11.2 mm. The presence of feroniellin B is possibly linked to the ethnopharmacological use of F. lucida as a remedy for cardiovascular diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ptr.2096 | DOI Listing |
Publication Analysis
Top Keywords
platelet aggregation
12
feroniellin highly
8
human platelet
8
feroniella lucida
8
highly potent
4
potent human
4
aggregation inhibitor
4
inhibitor feroniella
4
lucida human
4
aggregation inhibition
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!