Drug evaluation: lexatumumab, an intravenous human agonistic mAb targeting TRAIL receptor 2.

Curr Opin Mol Ther

University of Tübingen, Department of Radiation Oncology, Hoppe-Seyler-Str 3, D-72076, Tübingen, Germany.

Published: December 2006

Human Genome Sciences Inc, under license from Cambridge Antibody Technology Ltd, is developing lexatumumab, an intravenous human agonistic mAb to TNF-related apoptosis-inducing ligand (TRAIL) receptor 2, for the potential treatment of cancer. Phase II clinical trials of lexatumumab are underway.

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