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Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs. | LitMetric
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Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs.

Boris V Nikonenko Marina Protopopova Rowena Samala Leo Einck Carol A Nacy

Antimicrob Agents Chemother

Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA.

Published: April 2007

Substitution of the new diamine antibiotic SQ109 for ethambutol in a mouse model of chronic tuberculosis (TB) improved efficacy of combination drug therapy with first-line TB drugs rifampin and isoniazid, with or without pyrazinamide: at 8 weeks, lung bacteria were 1.5 log10 lower in SQ109-containing regimens.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855523PMC
http://dx.doi.org/10.1128/AAC.01326-06DOI Listing

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