Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells.

Bioorg Med Chem Lett

Lo Ka Chung Centre for Natural Anti-Cancer Drug Development, Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, PR China.

Published: March 2007

A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.

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http://dx.doi.org/10.1016/j.bmcl.2006.12.039DOI Listing

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