This paper introduces Set-based Cascading Approach for Medical Image Segmentation (SCAMIS), a new methodology for segmentation of medical imaging by integrating a number of algorithms. Existing approaches typically adopt the pipeline methodology. Although these methods provide promising results, the results generated are still susceptible to over-segmentation and leaking. In our methodology, we describe how set operations can be utilized to better overcome these problems. To evaluate the effectiveness of this approach, Magnetic Resonance Images taken from a teaching hospital research programme have been utilised, to reflect the real world quality needed for testing in patient datasets. A comparison between the pipeline and set-based methodology is also presented.
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IEEE Trans Image Process
December 2021
Segmenting complex 3D geometry is a challenging task due to rich structural details and complex appearance variations of target object. Shape representation and foreground-background delineation are two of the core components of segmentation. Explicit shape models, such as mesh based representations, suffer from poor handling of topological changes.
View Article and Find Full Text PDFJ Am Chem Soc
January 2016
Institute for Organic Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
Generating molecular complexity using a single catalyst, where the requisite activation modes are sequentially exploited as the reaction proceeds, is an attractive guiding principle in synthesis. This requires that each substrate transposition exposes a catalyst activation mode (AM) to which all preceding or future intermediates are resistant. While this concept is exemplified by MacMillan's beautiful merger of enamine and iminium ion activation, examples in other fields of contemporary catalysis remain elusive.
View Article and Find Full Text PDFJ Digit Imaging
June 2013
Developmental Imaging, Murdoch Childrens Research Institute, Parkville, Melbourne, Australia.
Craniofacial disorders are routinely diagnosed using computed tomography imaging. Corrective surgery is often performed early in life to restore the skull to a more normal shape. In order to quantitatively assess the shape change due to surgery, we present an automated method for intracranial space segmentation.
View Article and Find Full Text PDFBioinformatics
February 2012
Department of Computer Science, University of New Orleans, New Orleans, LA 70148, USA.
Motivation: A plethora of bioinformatics analysis has led to the discovery of numerous gene sets, which can be interpreted as discrete measurements emitted from latent signaling pathways. Their potential to infer signaling pathway structures, however, has not been sufficiently exploited. Existing methods accommodating discrete data do not explicitly consider signal cascading mechanisms that characterize a signaling pathway.
View Article and Find Full Text PDFIET Syst Biol
March 2010
Universitat Stuttgart, Institute for Systems Theory and Automatic Control, Germany.
One of the most challenging tasks in systems biology is parameter identification from experimental data. In particular, if the available data are noisy, the resulting parameter uncertainty can be huge and should be quantified. In this work, a set-based approach for parameter identification in discrete time models of biochemical reaction networks from time series data is developed.
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