Artemisia annua L. seeds from North Viet Nam were germinated and continuously propagated by tissue culture technique. Three-week-old plantlets were transplanted from the laboratory into the field under tropical climatic conditions and assayed for artemisinin at different stages of growth. The plants had short stature (100 cm), early flowering (14 weeks), short growth span (18-20 weeks), variable artemisinin content and produced no seeds. The highest artemisinin yield was found in the leaves of twelve (0.13-0.31%) to thirteen (0.12-0.39%) weeks old plants during pre-flowering periods. Plantlets in the test tubes were randomly selected and cloned. Statistical comparison of the artemisinin content from the various clones indicated that they may be grouped as high (0.41-0.42%), moderate (0.25-0.26%), and low (0.13%) artemisinin yielders.
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http://dx.doi.org/10.1055/s-2006-958078 | DOI Listing |
Front Microbiol
January 2025
School of Life Sciences, Hebei University, Baoding, China.
Introduction: Exploring the interactions between dark septate endophytes (DSE) in plant roots across diverse heavy metal habitats-considering host plants, site characteristics, and microbial communities-provides insights into the distribution patterns of DSE in metal-rich environments and their mechanisms for developing heavy metal resistance.
Methods: This study collected samples of three common plant species (, PA, , SV, and , AA) and their corresponding soil samples from three heavy metal-contaminated sites: Baiyang Lake, BY, Fengfeng mining area, FF, and Huangdao, HD. Utilizing high-throughput sequencing and physicochemical analysis methods, the biological and abiotic factors affecting DSE colonization and distribution in the roots were investigated.
Acta Trop
January 2025
Centre of Excellence for Pharmaceutical Sciences (Pharmacen(TM)), North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:
Praziquantel is currently the only effective treatment for schistosomiasis, but several limitations underscore the need for new therapeutic agents. Recent promising in vitro results with Artemisia species and the success of A. annua and its active compound artemisinin in treating parasitic infections warrant the need for further studies.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Colorectal cancer (CRC) remains a major global health burden, necessitating innovative preventive approaches. (), known for its extensive pharmacological properties, has shown potential in cancer therapy. This study investigates the chemopreventive efficacy of methanolic extract of (MEA) in an azoxymethane (AOM)-induced murine model of CRC, with a focus on its antioxidant, biomarker modulation, and pro-apoptotic activities.
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Background: Sheep coccidiosis could disturb the balance of intestinal microbiota, causing diarrhea, and even death in lambs. Chemical drugs are the primary method of treating sheep coccidiosis, but their use will bring drug resistance, toxic side effects, drug residues, and other problems. Chinese herbal medicines are investigated as alternative methods for controlling coccidian infections.
View Article and Find Full Text PDFMolecules
January 2025
Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Artemisinin is a sesquiterpene lactone derived from the plant L., renowned for its antimalarial activity. Based on this compound, various derivatives and analogues have been obtained that exhibit diverse biological activities, including clinically approved drugs.
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