From the non-coloured fraction of rhizomes of Aristolochia brevipes (Aristolochiaceae) the new aporphine alkaloid 6a,7-dehydro- N-formylnornantenine was isolated besides N-formylnornantenine, cadalene, and 4-hydroxy-4,7-dimethyl-1-tetralone.
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http://dx.doi.org/10.1055/s-2006-958049 | DOI Listing |
An Acad Bras Cienc
March 2018
Instituto de Química, Departamento de Productos Naturales, Universidad Nacional Autónoma de México, 04510 México, DF, México.
In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.
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July 2012
Laboratory of Microbiology, Biomedical Research Center of the South (IMSS), Argentina 1, Col. Centro, Xochitepec, Morelos, Mexico. .
Biotransformation processes have been successfully utilized to obtain products of pharmaceutical, chemical, food, and agricultural interest, which are difficult to obtain by classic chemical methods. The compound with antituberculous activity, 9-methoxy-tariacuripyrone (1), isolated from Aristolochia brevipes, was submitted to biotransformation with the yeast Saccharomyces cerevisiae under culture, yielding 5-amino-9-methoxy-3,4-dihydro-2H-benzo[h]chromen-2-one (2). The structure of (2) was elucidated on the basis of spectroscopic analyses.
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August 2011
Laboratory of Microbiology, Biomedical Research Center of the South (IMSS), Argentina 1, Col. Centro, 62790 Xochitepec, Morelos, Mexico.
The increased incidence of Multidrug-Resistant Mycobacterium tuberculosis (MDR-MT) requires the search for alternative antimycobacterial drugs. The main aim of this study was to evaluate the dichloromethane extract from Aristolochia brevipes (Rhizoma) and the compounds isolated from this extract against several mycobacterial strains, sensitive, resistant (monoresistant), and clinical isolates (multidrug-resistant), using the alamarBlue™ microassay. The extract was fractionated by column chromatography, yielding the following eight major compounds: (1) 6α-7-dehydro-N-formylnornantenine; (2) E/Z-N-formylnornantenine; (3) 7,9-dimethoxytariacuripyrone; (4) 9-methoxy-tariacuripyrone; (5) aristololactam I; (6) β-sitosterol; (7) stigmasterol; and (8) 3-hydroxy-α-terpineol.
View Article and Find Full Text PDFFrom the non-coloured fraction of rhizomes of Aristolochia brevipes (Aristolochiaceae) the new aporphine alkaloid 6a,7-dehydro- N-formylnornantenine was isolated besides N-formylnornantenine, cadalene, and 4-hydroxy-4,7-dimethyl-1-tetralone.
View Article and Find Full Text PDF9-Methoxytariacuripyrone, a nitro-aromatic compound isolated from Aristolochia brevipes showed strong mutagenic activity in strain TA98, TA100 and some YG strains of Salmonella typhimurium with and without S9 mix. Incubation with cytosol resulted in a heavy increase in mutagenicity. When incubated with microsomes the activity was dramatically decreased.
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