An 85-year-old man had a bilateral periorbital rash and conjunctivitis leading to lower eyelid ectropion and epiphora within 6 weeks of treatment with erlotinib (Tarceva, Genentech, Inc., San Francisco, CA, and OSI Pharmaceuticals, Melville, NY), a second-line antineoplastic agent. The treatment was discontinued secondary to toxicity, and the periorbital rash completely resolved within 6 weeks of cessation of the drug. To our knowledge, the periorbital rash resulting in bilateral lower eyelid ectropion associated with epiphora is a newly recognized side effect of erlotinib that is completely reversible with discontinuation of the drug. The rash and ectropion should be treated palliatively, and surgical intervention should be avoided unless the patient cannot be removed from treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/IOP.0b013e31802d97f0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Management of Orofacial Infantile Haemangioma: A Case Report.
Case Rep Dent
December 2024
Department of Paediatric Dentistry, Selayang Hospital (Ministry of Health), Batu Caves, Selangor, Malaysia.
Infantile haemangioma (IH) is the most common childhood tumour, often developing in the head and neck region. It may cause disfigurement, functional impairment, or tooth developmental issues when it is present in the oral cavity. We report a case of a 2-month-old boy referred to the paediatric dentistry team with a segmental IH involving the left periorbital, cheek, and hard palate.
View Article and Find Full Text PDFA Case Report on Dermatomyositis in a Female Patient with Facial Rash and Swelling.
J Educ Teach Emerg Med
October 2024
University of Texas Southwestern Medical Center, Department of Emergency Medicine, Dallas, Tx.
Unlabelled: Early diagnosis of rheumatologic diseases can improve patient outcomes. While clinical presentations of rheumatologic diseases can be vague, dermatomyositis (DM) has distinctive cutaneous findings that can clue in providers towards the diagnosis. This is a case report of a 49-year-old female who presented with progressive facial swelling, rash, and generalized myalgias for a month.
View Article and Find Full Text PDF14-month-old female with anti-MDA5 juvenile dermatomyositis complicated by liver disease: a case report.
Pediatr Rheumatol Online J
September 2024
Division of Rheumatology, Children's Mercy Hospital, Kansas City, MO, USA.
Article Synopsis
- Juvenile Dermatomyositis (JDM) is a rare autoimmune disorder with various subtypes, and anti-MDA5 is one of the associated myositis-specific antibodies, though treatment protocols are not well defined.
- A case study details a previously healthy 14-month-old girl with anti-MDA5 JDM presenting symptoms like rash, weakness, and liver issues, ultimately responding well to treatment with steroids and tofacitinib.
- This case highlights the importance of considering anti-MDA5 JDM when diagnosing patients with liver, muscle, and skin symptoms, emphasizing the need for standardized treatment approaches and more research into the mechanisms of the disease.
A 29-year-old female presented to a rheumatology-dermatology clinic with a pruritic rash that began 6 months prior, after a viral illness. She had previously been diagnosed with eczema and treated with antihistamines and topical steroids without improvement. She also noted fatigue, hair loss, and severe scalp pruritus.
View Article and Find Full Text PDFMonkeypox Presenting as Periorbital Cellulitis: A Case Report.
Cureus
July 2024
Infectious Disease, Hospital Corporation of America (HCA) Florida Osceola Hospital, Kissimmee, USA.
Article Synopsis
- Monkeypox is a viral disease known for its distinctive rash that evolves through different skin stages, and it can also affect other body systems like respiratory and gastrointestinal.
- The illness often starts with flu-like symptoms before skin symptoms develop, but in this case, a patient initially showed periorbital cellulitis without any skin rash.
- The source of the infection was unidentified, but the patient recovered completely, highlighting the importance of thorough evaluations for unusual presentations of monkeypox.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!