AI Article Synopsis
- The study examined the link between inherited and acquired thrombophilia and venous thromboembolic events (TE) in 114 adult acute leukemia patients.
- The most common risk factor identified was hyperhomocysteinemia, present in 46.6% of patients, contributing to a TE incidence of 9.6%, primarily within the first month.
- Hyperhomocysteinemia stood out as the only significant risk factor in the analysis, suggesting that monitoring homocysteine levels could help assess early TE risk, while routine thrombophilia screening may not be necessary.
Article Abstract
Inherited and acquired thrombophilia are associated with venous thromboembolic events (TE). The prevalence of inherited and acquired prothrombotic risk factors and the incidence of symptomatic TE were evaluated in a cohort of 114 adult acute leukemia patients. The most frequent prothrombotic risk factor was hyperhomocysteinemia which occurred in 46.6% of patients. The incidence of TE was 9.6%, mainly in the first month of follow-up. In multivariate analysis, hyperhomocysteinemia was the only risk factor for TE (OR 33.90; 95% CI 1.53-751.33; p = 0.026). The results of this study indicate that measurements of homocysteinemia could be useful in determining the risk of early TE in adult acute leukemia patients, while systematic thrombophilia screening should not be justified.
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| http://dx.doi.org/10.1159/000098700 | DOI Listing |
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