Background: A new intracellular adenosine triphosphate (ATP) delivery technique has been developed and was tested for skin wound care.
Methods: Eleven pairs of adult nude mice were used. ATP-vesicles were applied in 11 mice, and another 11 mice were treated with lipid vesicles only.
Results: The group treated with ATP-encapsulated fusogenic small, unilamellar lipid vesicles healed faster than the group treated with only lipid vesicles. Histologic study indicated better developed granular tissue and re-epithelialization in the study group, and wound tissue vascular endothelial growth factor expressions were also higher in ATP-vesicles treated mice.
Conclusions: This intracellular ATP delivery system may provide a new hope for wound healing as well as the treatment of medical conditions in which ischemia is involved.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850226 | PMC |
| http://dx.doi.org/10.1016/j.amjsurg.2006.08.069 | DOI Listing |
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