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[Identification of Food-derived Bioactive Components with Physiological Effects].
Yakugaku Zasshi
January 2025
Faculty of Applied Biosciences, Tokyo University of Agriculture.
Food-derived components with physiological effects have been attracting attention in recent years, and studies have comprehensively analyzed these components. In this study, we sought to identify food components with functional properties for the prevention and improvement of metabolic syndrome. We performed a luciferase reporter assay using fatty acid synthase (FAS) and low-density lipoprotein receptor (LDL) receptor gene promoters.
View Article and Find Full Text PDFArctiin alleviates the progression of osteoarthritis by regulating the cholesterol metabolic pathway.
Sci Rep
January 2025
Guangzhou First People's Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology; Guangzhou First People's Hospital, Guangzhou Medical University, 1 Panfu Road, Yuexiu District, Guangzhou, 510180, China.
Osteoarthritis (OA) is a multi-factorial degenerative joint disease with unclear pathogenesis. Conservative treatments, primarily aimed at pain relief, fail to halt disease progression. Metabolic syndrome has recently been implicated in OA pathogenesis, underscoring the need for novel therapeutic strategies.
View Article and Find Full Text PDFEarly alterations of functional connectivity, regional brain volumes and astrocyte markers in the beta-sitosterol beta-d-glucoside (BSSG) rat model of parkinsonism.
Exp Neurol
March 2025
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Basic and Clinical Neuroscience, King's College London, London, UK. Electronic address:
The β-sitosterol-β-ᴅ-glucoside (BSSG) rat model of experimental parkinsonism develops pathological behaviour and motor changes that progress over time. The purpose of this study was to identify early changes in structure and function of the brain of rats treated with BSSG using both structural and resting-state functional MRI. BSSG and non-BSSG rats were fed five days a week for sixteen weeks, then underwent in vivo MRI scans and an assessment of motor performance 2 and 8 weeks later (18 and week 24 from BSSG).
View Article and Find Full Text PDFThermal stability of stigmasterol and β-sitosterol glucosides in fresh-cut bitter melon fruit.
Food Chem
March 2025
Graduate School of Green-Bio Science, College of Life Sciences, Kyung Hee University, Yongin 17104, South Korea. Electronic address:
Charantin in M. charantia fruit comprises stigmasterol glucoside (STG) and β-sitosterol glucoside (BSG). Despite numerous studies on charantin quantification and health beneficial bioactivity, thermal stability of two components remains unclear.
View Article and Find Full Text PDFAntibacterial activity of withanolides, labdane glucosides, flavonoids and other constituents from two populations of Physalis patula.
Fitoterapia
January 2025
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Col. Juriquilla 76230, Querétaro, Qro., Mexico. Electronic address:
Two populations of Physalis patula Miller collected in different localities (Querétaro and Teotihuacán) of Central México were analyzed. Eight new compounds including three withanolides, physapatolides A-C (1-3), two labdanes, 12-epi-physacoztomatin (10) and physapatulone (12), besides three 12-O-glucosyl labdanes, patulosides A-C (13-15), were isolated from these collections. A series of known withanolides, flavonoids, labdanes, sucrose esters, and sterols were also isolated.
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