With the completion of the Human Genome Project, a new emphasis is focusing on the sequence variation and the resulting phenotype. The number of data available from genomic studies addressing this relationship is rapidly growing. In order to analyze these data as a whole, they need to be integrated, aggregated and annotated in a timely manner. The Pharmacogenetics and Pharmacogenomics Knowledge Base PharmGKB; (
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VM-UNet++ research on crack image segmentation based on improved VM-UNet.
Sci Rep
March 2025
School of Transportation and Logistics, East China Jiaotong University, Nanchang, 330013, China.
Cracks are common defects in physical structures, and if not detected and addressed in a timely manner, they can pose a severe threat to the overall safety of the structure. In recent years, with advancements in deep learning, particularly the widespread use of Convolutional Neural Networks (CNNs) and Transformers, significant breakthroughs have been made in the field of crack detection. However, CNNs still face limitations in capturing global information due to their local receptive fields when processing images.
View Article and Find Full Text PDFA novel self-ratiometric fluorescent sensor of sodium alginate hydrogel bead doping with coumarin derivative with extremely acidic pH visual monitoring of fruit juice freshness.
Int J Biol Macromol
March 2025
Food Microbiology Key Laboratory of Sichuan Province, College of Food and Bioengineering, Xihua University, Chengdu 610039, PR China.
The slight acidic pH changes during food storage and transportation are often difficult to detect in a timely and accurate manner. There is also an urgent need to establish a portable, accurate, and low interference detection method for real-time monitoring of the quality changes of fresh juice that already has its own color. In this paper, a self-ratiometric fluorescent sensor (DCCA/SA bead) was prepared by combining a modified coumarin and sodium alginate (SA), and was used for the extreme pH monitoring of fluorescent by naked eye colorimetry.
View Article and Find Full Text PDFDelays beyond Five Days to Surgery Does Not Affect Outcome Following Plate and Screw Fixation of Proximal Humerus Fractures.
J Shoulder Elbow Surg
March 2025
NYU Langone Orthopedic Hospital, NYU Langone Medical Center, New York, NY, USA. Electronic address:
Purpose: The purpose of this study is to compare the quality and clinical outcomes of patients who underwent open reduction internal fixation for a proximal humerus fracture in a "timely manner" which was defined to be within 5 days of injury compared to those with "delayed intervention" (>5 Days) to determine the effect this had.
Methods: This IRB-approved study evaluated patients who sustained a proximal humerus fracture treated with plate and screw fixation (ORIF) between January 2004 and October 2022 and had time from injury to surgery documented. Patients were grouped based on the time to surgery (TTS) - Less than 5 Days (L5) vs.
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling.
Cell Metab
March 2025
Department of Cardiovascular Medicine, Center for Circadian Metabolism and Cardiovascular Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China; Ministry of Education Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease, Chongqing 400038, China. Electronic address:
Feeding rhythms regulate exercise performance and muscle energy metabolism. However, the mechanisms regulating adipocyte functions remain unclear. Here, using multi-omics analyses, involving (phospho-)proteomics and lipidomics, we found that day-restricted feeding (DRF) regulates diurnal rhythms of the mitochondrial proteome, neutral lipidome, and nutrient-sensing pathways in mouse gonadal white adipose tissue (GWAT).
View Article and Find Full Text PDFCell envelope polysaccharide modifications alter the surface properties and interactions of with innate immune cells in a morphotype-dependent manner.
mBio
March 2025
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
is one of the leading causes of pulmonary infections caused by non-tuberculous mycobacteria. The ability of to establish a chronic infection in the lung relies on a series of adaptive mutations impacting, in part, global regulators and cell envelope biosynthetic enzymes. One of the genes under strong evolutionary pressure during host adaptation is , which participates in the elaboration of the arabinan domains of two major cell envelope polysaccharides: arabinogalactan (AG) and lipoarabinomannan (LAM).
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