AI Article Synopsis

  • Antimicrobial resistance (AMR) poses significant risks to critically ill patients, leading to treatment failures with serious outcomes.
  • Methicillin-resistant Staphylococcus aureus (MRSA) has been a major issue in Japan, alongside the rise of other drug-resistant pathogens such as VRE, MDRP, and ESBL in hospitals.
  • To combat AMR, it's essential to follow local sensitivity results for therapy and implement the CDC's 12 prevention steps, highlighting the need for more infectious disease specialists in Japan to help successfully manage these challenges.

Article Abstract

Antimicrobial-resistance (AMR) is a growing threat especially to critically ill patients, because treatment failure can have serious consequences. MRSA has been a major concern in Japanese hospitals, however, emerging the drug-resistant pathogens that comprise VRE, MDRP or ESBL have been reported as nosocomial infectious pathogens. To control antimicrobial-resistance, antimicrobial therapy according to local sensitivity result and multidisciplinary management is necessary. CDC recommends 12 steps to prevent AMR among hospitalized patients, which included prevent infection, diagnose and treat infection effectively, use antimicrobials wisely, and prevent transmission. Infectious diseases experts, who are far lacking in Japan, may play a key role to achieve these recommendations.

Download full-text PDF

Source

Publication Analysis

Top Keywords

[infection control
4
control strategies
4
strategies antimicrobial-resistance]
4
antimicrobial-resistance] antimicrobial-resistance
4
antimicrobial-resistance amr
4
amr growing
4
growing threat
4
threat critically
4
critically ill
4
ill patients
4

Similar Publications

Latent tuberculosis prevalence in healthcare workers in Laos: a cross-sectional study.

Trop Med Health

January 2025

LaoLuxLab/Vaccine Preventable Diseases Laboratory, Institut Pasteur du Laos, Vientiane, Laos.

Background: Individuals with latent tuberculosis infection (LTBI) have a high risk of active infection, morbidity and mortality. Healthcare workers are a group who have increased risk of infection and onward transmission to their patients and other susceptible individuals; however, LTBI is often undiagnosed, and individuals are asymptomatic. Interferon gamma release assays (IGRA) can detect evidence of TB infection in otherwise asymptomatic individuals and are a good indication of LTBI.

View Article and Find Full Text PDF

Objective: To investigate the application value of arthroscopic channel modification in meniscal injury repair.

Methods: We retrospectively analyzed the data of 100 patients with meniscus injuries treated with knee arthroscopy from December 2022 to December 2023 and divided them into a control group and a modified group according to the application of "arthroscopic access modification technology". We compared the operation time, postoperative hospitalization time, VAS score, Lysholm knee function score, postoperative complications, and postoperative images of the patients in these two groups.

View Article and Find Full Text PDF

Background: Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection (STI) primarily acquired through sexual contact. In 2000, the World Health Organization (WHO) for the first time reported the association of STIs with male infertility. Infertility is described as the inability to achieve a clinical pregnancy after engaging in regular, unprotected sexual intercourse for a year or more.

View Article and Find Full Text PDF

Prevalence of intestinal parasites and Helicobacter pylori co-infection in people with gastrointestinal symptoms in Africa: a systematic review and meta-analysis.

BMC Infect Dis

January 2025

Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Gastrointestinal infections caused by intestinal parasites and Helicobacter pylori are significant public health issues in Africa, where poor sanitation and limited access to healthcare contribute to high disease burden. Since there was no previous pooled data regarding the intestinal parasites and Helicobacter pylori co-infections among gastrointestinal symptomatic patients in the African context, this review aimed to determine the overall prevalence of intestinal parasites and Helicobacter pylori co-infection in people with gastrointestinal symptoms in Africa.

Methods: The current review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standards and registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42024598993).

View Article and Find Full Text PDF

Assessment of the impact of different SARS-CoV-2 inactivation operations on colistin sulfate plasma concentration results.

BMC Infect Dis

January 2025

Department of Cardiac Surgery, Second Hospital of Hebei Medical University, No.215 of Heping West Road,Xinhua District, Shijiazhuang, 050000, China.

Objective: To evaluate the effects of different SARS-CoV-2 inactivation methods on the blood concentration of colistin sulfate.

Methods: A colistin sulfate reference substance, a quality control plasma sample, and a clinically measured sample were transferred and heated in a 56 °C water batch for 30 min or irradiated under an ultraviolet (UV) lamp for 60 min to examine the stability of the reference solution and quality control plasma sample. Statistical analysis was conducted for the concentration of the clinically measured sample before and after inactivation with the intraclass correlation coefficient (ICC) method, the Passing-Bablok regression, and the Bland-Altman analysis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!